{"id":4821,"date":"2020-04-08T14:32:06","date_gmt":"2020-04-08T04:32:06","guid":{"rendered":"https:\/\/mvec.mcri.edu.au\/?p=4821"},"modified":"2021-01-27T17:59:41","modified_gmt":"2021-01-27T06:59:41","slug":"clinical-trial-of-bcg-vaccine-against-covid-19-brace","status":"publish","type":"post","link":"https:\/\/mvec.mcri.edu.au\/hi\/clinical-trial-of-bcg-vaccine-against-covid-19-brace\/","title":{"rendered":"Clinical trial of BCG vaccine against COVID-19 (BRACE)"},"content":{"rendered":"<p>Led by Professor Nigel Curtis, Researchers at Murdoch Children\u2019s Research Institute are conducting a randomised controlled clinical trial of the BCG vaccine against COVID-19. The study, known as the BRACE trial (BCG vaccination to Reduce the impact of COVID-19 in Australian healthcare workers following Coronavirus Exposure), has been endorsed by the Director-General of the WHO, Tedros Adhanom Ghebreyesus.<\/p>\n<p>Designed to provide protection against tuberculosis, the Bacille Calmette-Guerin (BCG) vaccine may also potentially provide immunity to protect against other infections. The purpose of the BRACE trial is to investigate whether or not BCG vaccination protects against COVID-19 or reduces the severity of symptoms of COVID-19 in healthcare workers.<\/p>\n<p>This has led to people who <strong>do not<\/strong> meet the criteria for the trial seeking to have the BCG vaccine.<\/p>\n<p>MVEC and physician BCG experts, have reached a consensus position on this issue, as detailed below:<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><span style=\"color: #ff0000;\">We strongly advise against anyone having BCG outside of a clinical trial, unless they meet criteria as per the <a style=\"color: #ff0000;\" href=\"https:\/\/immunisationhandbook.health.gov.au\/vaccine-preventable-diseases\/tuberculosis\">Australian Immunisation Handbook tuberculosis guidelines<\/a>.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"color: #ff0000;\">BCG vaccine is known to be effective in protecting young children from tuberculosis, and has been affected by global shortages in recent years.\u00a0 Using a vaccine (like BCG), for a non-proven use, carries risks to those vaccinated and those who prescribe it. Furthermore, additional use of BCG vaccine outside a trial, could lead to shortages for infants who need it to protect against tuberculosis. Many travel clinics providing BCG have been placed on-hold due to the current limitations on overseas travel.\u00a0 However, travel and hospital-based BCG clinics will aim to increase access to the vaccine when travel restrictions (including to tuberculosis endemic countries) are lifted.<\/span><\/p>\n<p>Authorised by:<\/p>\n<ul>\n<li>Dr Nigel Curtis, Dr Nigel Crawford, Dr Jim Buttery, Dr Shidan Tosif, Dr Daryl Cheng and Dr Teresa Lazzaro<br \/>-8th April 2020<\/li>\n<\/ul>\n<p>\u0938\u0902\u0938\u093e\u0927\u0928:<\/p>\n<ul>\n<li><a href=\"https:\/\/mcri.edu.au\/BRACE\" target=\"_blank\" rel=\"noopener noreferrer\">MCRI: BCG vaccination to Reduce the impact of COVID-19 in Australian healthcare workers following Coronavirus Exposure (BRACE) Trial<\/a><\/li>\n<li><a href=\"https:\/\/www.mcri.edu.au\/news\/murdoch-children\u2019s-research-institute-trial-preventative-vaccine-covid-19-healthcare-workers\" target=\"_blank\" rel=\"noopener noreferrer\">MCRI: Murdoch Children\u2019s Research Institute to trial preventative vaccine for COVID-19 healthcare workers<\/a><\/li>\n<li><a href=\"https:\/\/mvec.mcri.edu.au\/immunisation-references\/bcg-vaccine\/\">MVEC: BCG vaccine<\/a> (including BCG clinics in Victoria)<\/li>\n<li><a href=\"https:\/\/immunisationhandbook.health.gov.au\/vaccine-preventable-diseases\/tuberculosis\" target=\"_blank\" rel=\"noopener noreferrer\">\u0911\u0938\u094d\u091f\u094d\u0930\u0947\u0932\u093f\u092f\u093e\u0908 \u091f\u0940\u0915\u093e\u0915\u0930\u0923 \u092a\u0941\u0938\u094d\u0924\u093f\u0915\u093e: \u0915\u094d\u0937\u092f \u0930\u094b\u0917<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"Led by Professor Nigel Curtis, Researchers at Murdoch Children\u2019s Research Institute are conducting a randomised controlled clinical trial of the","protected":false},"author":493,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":"","_wp_rev_ctl_limit":""},"categories":[87,8,10],"tags":[38,39],"class_list":["post-4821","post","type-post","status-publish","format-standard","hentry","category-news","category-covid-19","category-external","tag-covid19","tag-brace"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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