{"id":7175,"date":"2014-07-08T09:58:01","date_gmt":"2014-07-07T23:58:01","guid":{"rendered":"http:\/\/www.mvec.vic.edu.au\/?page_id=437"},"modified":"2024-12-19T11:24:55","modified_gmt":"2024-12-19T00:24:55","slug":"%e0%a4%b9%e0%a5%87%e0%a4%aa%e0%a5%87%e0%a4%9f%e0%a4%be%e0%a4%87%e0%a4%9f%e0%a4%bf%e0%a4%b8-%e0%a4%ac%e0%a5%80","status":"publish","type":"references","link":"https:\/\/mvec.mcri.edu.au\/hi\/references\/hepatitis-b\/","title":{"rendered":"\u0939\u0947\u092a\u0947\u091f\u093e\u0907\u091f\u093f\u0938 \u092c\u0940"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div data-parent=\"true\" class=\"vc_row row-container\" id=\"row-unique-0\"><div class=\"row single-top-padding single-bottom-padding one-h-padding full-width row-parent\"><div class=\"wpb_row row-inner\"><div class=\"wpb_column pos-top pos-center align_left column_parent col-lg-12 single-internal-gutter\"><div class=\"uncol style-light\"  ><div class=\"uncoltable\"><div class=\"uncell no-block-padding\" ><div class=\"uncont\" ><div class=\"uncode_text_column\" ><\/p>\n<h2>What is it?<\/h2>\n<p><span data-contrast=\"none\">Hepatitis B is an infection caused by the <\/span><i><span data-contrast=\"none\">hepatitis B virus <\/span><\/i><span data-contrast=\"none\">(HBV). It can affect both adults and children, causing acute liver inflammation.<\/span><\/p>\n<p><span data-contrast=\"none\">Once acute infection has resolved, it is estimated that up to 10% of those infected in adulthood, and up to 90% of those infected in infancy, will go on to develop chronic infection.<\/span><\/p>\n<p><span data-contrast=\"none\">Chronic hepatitis B (CHB) can lead to cirrhosis (scarring of the liver) and liver failure and\/or <\/span><span data-contrast=\"none\">hepatocellular carcinoma<\/span><span data-contrast=\"none\"> (liver cancer<\/span><span data-contrast=\"none\">). Liver cancer is the second leading cause of cancer deaths globally. There is no cure for CHB, although there are some antiviral medications that can reduce potential liver damage.<\/span><\/p>\n<h2>What to look for<\/h2>\n<p><span data-contrast=\"none\">The incubation period for hepatitis B ranges from 45 to 180\u202fdays. The infectious period starts from several weeks before the onset of symptoms <\/span><span data-contrast=\"none\">(if present)<\/span><span data-contrast=\"none\">, and usually lasts approximately 4 to 5\u202fmonths. Those who develop CHB\u202fusually remain infectious for life.<\/span><\/p>\n<p><span data-contrast=\"none\">Initial hepatitis B infection is often asymptomatic, meaning a person may be unaware that they are carrying the infection. In those who develop signs of acute hepatitis B infection, symptoms may include:<\/span><\/p>\n<ul>\n<li><span data-contrast=\"none\">loss of appetite<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">nausea and vomiting<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">abdominal pain\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">fever<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">pain in the joints<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">jaundice (yellowing of the skin and eyes).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span class=\"TextRun SCXW199638807 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW199638807 BCX0\">HBV infection is confirmed <\/span><span class=\"NormalTextRun SCXW199638807 BCX0\">via <\/span><span class=\"NormalTextRun SCXW199638807 BCX0\">a <\/span><span class=\"NormalTextRun CommentStart CommentHighlightPipeRest CommentHighlightRest SCXW199638807 BCX0\">blood test<\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW199638807 BCX0\"><span class=\"TextRun SCXW199638807 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun CommentHighlightRest SCXW199638807 BCX0\"> (serology), which may also be used to <\/span><\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW199638807 BCX0\"><span class=\"TextRun SCXW199638807 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun CommentHighlightRest SCXW199638807 BCX0\">determine<\/span><span class=\"NormalTextRun CommentHighlightRest SCXW199638807 BCX0\"> whether infections are newly <\/span><span class=\"NormalTextRun CommentHighlightRest SCXW199638807 BCX0\">acquired<\/span><span class=\"NormalTextRun CommentHighlightRest SCXW199638807 BCX0\"> or chronic<\/span><\/span><\/span><span class=\"TextRun SCXW199638807 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun CommentHighlightPipeRest SCXW199638807 BCX0\">.<\/span><\/span><\/p>\n<h2><span class=\"TextRun MacChromeBold SCXW222888055 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW222888055 BCX0\" data-ccp-parastyle=\"Intense Quote\">How is it transmitted?<\/span><\/span><\/h2>\n<p><span class=\"TextRun SCXW141495923 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW141495923 BCX0\">Hepatitis B<\/span> <span class=\"NormalTextRun SCXW141495923 BCX0\">is <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">transmitted<\/span> <span class=\"NormalTextRun SCXW141495923 BCX0\">through broken <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">or penetrated ski<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">n<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">,<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\"> or<\/span> <span class=\"NormalTextRun SCXW141495923 BCX0\">when a person\u2019s <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">mucosal<\/span> <span class=\"NormalTextRun SCXW141495923 BCX0\">surface (nose, <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">eyes<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\"> or mouth) is exposed <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">to<\/span> <span class=\"NormalTextRun SCXW141495923 BCX0\">blood<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">, <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">semen<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\"> or <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">other <\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">body <\/span><span class=\"NormalTextRun CommentStart SCXW141495923 BCX0\">fluids<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\"> of an infected person<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">.<\/span> <span class=\"NormalTextRun SCXW141495923 BCX0\">Transmission can oc<\/span><span class=\"NormalTextRun SCXW141495923 BCX0\">cur:<\/span><\/span><\/p>\n<ul>\n<li><span data-contrast=\"auto\">from an infected mother to baby during delivery<\/span><\/li>\n<li><span data-contrast=\"auto\">during sexual contact<\/span><\/li>\n<li><span data-contrast=\"auto\">with exposure to contaminated sharp objects (e.g. during tattoos or piercings, or injecting drugs)<\/span><\/li>\n<li><span data-contrast=\"none\">through sharing a toothbrush or razor<\/span><\/li>\n<li><span data-contrast=\"none\">through contact with contaminated surfaces<\/span><span data-contrast=\"none\">.<\/span><\/li>\n<\/ul>\n<p><span class=\"NormalTextRun SCXW127885883 BCX0\">HBV<\/span><span class=\"NormalTextRun SCXW127885883 BCX0\"> can survive <\/span><span class=\"NormalTextRun SCXW127885883 BCX0\">on surfaces for at least 7 days<\/span><span class=\"NormalTextRun SCXW127885883 BCX0\"> and <\/span><span class=\"NormalTextRun SCXW127885883 BCX0\">rema<\/span><span class=\"NormalTextRun SCXW127885883 BCX0\">ins<\/span><span class=\"NormalTextRun SCXW127885883 BCX0\"> capable of causing infection<\/span><span class=\"NormalTextRun SCXW127885883 BCX0\"> during this time<\/span><span class=\"NormalTextRun SCXW127885883 BCX0\">.<\/span><\/p>\n<h2>Epidemiology<\/h2>\n<p><span class=\"TextRun SCXW35296000 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35296000 BCX0\">Humans are the only known <\/span><span class=\"NormalTextRun SCXW35296000 BCX0\">host for HBV. <\/span><span class=\"NormalTextRun SCXW35296000 BCX0\">Around <\/span><span class=\"NormalTextRun SCXW35296000 BCX0\">296 million people globally <\/span><span class=\"NormalTextRun SCXW35296000 BCX0\">are <\/span><span class=\"NormalTextRun SCXW35296000 BCX0\">living<\/span><span class=\"NormalTextRun SCXW35296000 BCX0\"> with <\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW35296000 BCX0\"><span class=\"TextRun SCXW35296000 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35296000 BCX0\">CHB<\/span><\/span><\/span><span class=\"TextRun SCXW35296000 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35296000 BCX0\">.<\/span><\/span><\/p>\n<p><span data-contrast=\"none\">In Australia, it is estimated that there are over 200,000 people living with diagnosed CHB, representing around three quarters of the total number of cases (with one quarter remaining undiagnosed). Over 90% of new CHB cases in Australia are contracted overseas.<\/span><\/p>\n<p><span data-contrast=\"none\">Aboriginal and Torres Strait Islander peoples, people who inject drugs, men who have sex with men (MSM), and those born in areas endemic with HBV carry the highest burden of disease in Australia.<\/span><\/p>\n<h2><span class=\"TextRun MacChromeBold SCXW97015892 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW97015892 BCX0\" data-ccp-parastyle=\"Intense Quote\">Prevention<\/span><\/span><\/h2>\n<p><span data-contrast=\"none\">The spread of hepatitis B can be reduced by:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li><span data-contrast=\"none\">promoting and <\/span><span data-contrast=\"none\">practic<\/span><span data-contrast=\"none\">ing safe sex<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559737&quot;:-20,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">not sharing <\/span><span data-contrast=\"none\">injecting<\/span><span data-contrast=\"none\">, piercing or tattooing<\/span><span data-contrast=\"none\"> equipment<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559737&quot;:-20,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">maintaining infection control measures in healthcare settings<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559737&quot;:-20,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">washing your hands thoroughly with soap and water after any contact with blood, body fluids, or contaminated surfaces<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559737&quot;:-20,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">ensuring appropriate antenatal care, including HBsAg screening<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559737&quot;:-20,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">vaccination.<\/span><\/li>\n<\/ul>\n<h3>Vaccination<\/h3>\n<p><span data-contrast=\"none\">Vaccination provides <\/span><span data-contrast=\"none\">high le<\/span><span data-contrast=\"none\">vels<\/span><span data-contrast=\"none\"> of protection against HBV infection. <\/span><span data-contrast=\"none\">In Australia, v<\/span><span data-contrast=\"none\">accination is available through either monovalent or combination vaccines.<\/span><\/p>\n<p><span data-contrast=\"none\">Hepatitis B vaccination is funded <\/span><span data-contrast=\"none\">via the <\/span><a href=\"https:\/\/www.health.gov.au\/resources\/publications\/national-immunisation-program-schedule?language=en\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">National Immunisation Program (NIP)<\/span><\/a>;<span data-contrast=\"none\">\u00a0<\/span><span data-contrast=\"none\">a single dose <\/span><span data-contrast=\"none\">for<\/span><span data-contrast=\"none\"> neonates at birth<\/span> <span data-contrast=\"none\">and a 3-dose course given <\/span><span data-contrast=\"none\">at 6 weeks, 4 months and 6 months of age.\u00a0<\/span><span data-contrast=\"none\">Additional<\/span><span data-contrast=\"none\">\u00a0doses and<\/span><span data-contrast=\"none\">\/or<\/span><span data-contrast=\"none\">\u00a0boosters\u00a0<\/span><span data-contrast=\"none\">are recommended for certain groups (e.g.\u00a0<a href=\"https:\/\/mvec.mcri.edu.au\/references\/preterm-infant-immunisation\/\">preterm babies<\/a>, people with renal failure and those with\u00a0<a href=\"https:\/\/mvec.mcri.edu.au\/references\/immunosuppression-and-vaccines\/\">immunosuppression<\/a>).\u00a0<\/span><\/p>\n<p><span class=\"TrackChangeTextInsertion TrackedChange SCXW183382105 BCX0\"><span class=\"TextRun SCXW183382105 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183382105 BCX0\">The birth dose of hepatitis B vaccine is recommended to prevent transmission of HBV <\/span><\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW183382105 BCX0\"><span class=\"TextRun SCXW183382105 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183382105 BCX0\">during childbirth. D<\/span><\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW183382105 BCX0\"><span class=\"TextRun SCXW183382105 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183382105 BCX0\">ue to the long incubation period and high rates of asymptomatic infection, administration<\/span><\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW183382105 BCX0\"><span class=\"TextRun SCXW183382105 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183382105 BCX0\">\u00a0is recommended <\/span><\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW183382105 BCX0\"><span class=\"TextRun SCXW183382105 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183382105 BCX0\">regardless of a mother\u2019s infection stat<\/span><\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW183382105 BCX0\"><span class=\"TextRun SCXW183382105 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183382105 BCX0\">us.\u00a0<\/span><\/span><\/span><\/p>\n<p><strong><span class=\"TextRun SCXW235674990 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW235674990 BCX0\">Table 1: Hepatitis B vaccine brands and schedules available in Australia<\/span><\/span><\/strong><span class=\"EOP SCXW235674990 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/div>\n\t<div class=\"wpb_raw_code wpb_raw_html \" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<div class=\"supsystic-table-loader spinner\"style=\"background-color:#000000\"><\/div><div id=\"supsystic-table-127_58595\" class=\"supsystic-tables-wrap \" style=\" width:100%; visibility: hidden; \" data-table-width-fixed=\"100%\" data-table-width-mobile=\"100%\" ><table id=\"supsystic-table-127\" class=\"supsystic-table paragraphMode border stripe lightboxImg cell-border\" data-id=\"127\" data-view-id=\"127_58595\" data-title=\"Hepatitis B vaccine brands available in Australia\" data-currency-format=\"$1,000.00\" data-percent-format=\"10.00%\" data-date-format=\"DD.MM.YYYY\" data-time-format=\"HH:mm\" data-features=\"[&quot;after_table_loaded_script&quot;]\" data-search-value=\"\" data-loader-icon-name=\"default\" data-loader-icon-items=\"0\" data-loader-color=\"#000000\" data-processing-bg=\"#ffffff\" data-processing-color=\"#000000\" data-lightbox-img=\"\" data-head-rows-count=\"1\" data-pagination-length=\"50,100,All\" data-auto-index=\"off\" data-searching-settings=\"{&quot;columnSearchPosition&quot;:&quot;bottom&quot;,&quot;minChars&quot;:&quot;0&quot;}\" data-lang=\"default\" data-override=\"{&quot;emptyTable&quot;:&quot;&quot;,&quot;info&quot;:&quot;&quot;,&quot;infoEmpty&quot;:&quot;&quot;,&quot;infoFiltered&quot;:&quot;&quot;,&quot;lengthMenu&quot;:&quot;&quot;,&quot;search&quot;:&quot;&quot;,&quot;previous&quot;:&quot;&quot;,&quot;next&quot;:&quot;&quot;,&quot;zeroRecords&quot;:&quot;&quot;,&quot;exportLabel&quot;:&quot;&quot;,&quot;file&quot;:&quot;default&quot;}\" data-merged=\"[{&quot;row&quot;:1,&quot;col&quot;:0,&quot;rowspan&quot;:1,&quot;colspan&quot;:4,&quot;removed&quot;:false},{&quot;row&quot;:7,&quot;col&quot;:0,&quot;rowspan&quot;:1,&quot;colspan&quot;:4,&quot;removed&quot;:false},{&quot;row&quot;:2,&quot;col&quot;:3,&quot;rowspan&quot;:2,&quot;colspan&quot;:1,&quot;removed&quot;:false},{&quot;row&quot;:10,&quot;col&quot;:2,&quot;rowspan&quot;:2,&quot;colspan&quot;:1,&quot;removed&quot;:false},{&quot;row&quot;:10,&quot;col&quot;:0,&quot;rowspan&quot;:2,&quot;colspan&quot;:1,&quot;removed&quot;:false}]\" data-responsive-mode=\"2\" data-from-history=\"0\" ><thead><tr><th class=\"\" style=\"width:25%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:12%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:10%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:auto; padding: 0 !important;\"><\/th><\/tr><\/thead><tbody><tr style=\"height:px\" ><td data-cell-id=\"A1\" data-x=\"0\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold htMiddle htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"Vaccine brand and antigen\" data-order=\"Vaccine brand and antigen\" style=\"min-width: 25%; width: 25%;\" >Vaccine brand and antigen <\/td><td data-cell-id=\"B1\" data-x=\"1\" data-y=\"1\" data-db-index=\"1\" class=\"bg-3d5467 color-ffffff bold htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Age\" data-order=\"Age\" style=\"min-width: 12%; width: 12%;\" >Age <\/td><td data-cell-id=\"C1\" data-x=\"2\" data-y=\"1\" data-db-index=\"1\" class=\"bg-3d5467 color-ffffff bold htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Dose, hepatitis B antigen content and route\" data-order=\"Dose, hepatitis B antigen content and route\" style=\"min-width: 10%; width: 10%;\" >Dose, hepatitis B antigen content and route <\/td><td data-cell-id=\"D1\" data-x=\"3\" data-y=\"1\" data-db-index=\"1\" class=\"bg-3d5467 color-ffffff bold htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Recommended schedule*\" data-order=\"Recommended schedule*\" style=\"min-width: auto; width: auto;\" >Recommended schedule* <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A2\" data-x=\"0\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter color-ffffff bold bg-7ac79b\" data-cell-type=\"text\" data-original-value=\"Monovalent vaccines\" data-order=\"Monovalent vaccines\" data-colspan=\"4\" data-rowspan=\"1\" >Monovalent vaccines <\/td><td data-cell-id=\"B2\" data-x=\"1\" data-y=\"2\" data-db-index=\"2\" class=\"color-ffffff bold bg-7ac79b htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"C2\" data-x=\"2\" data-y=\"2\" data-db-index=\"2\" class=\"color-ffffff bold bg-7ac79b htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"D2\" data-x=\"3\" data-y=\"2\" data-db-index=\"2\" class=\"color-ffffff bold bg-7ac79b htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A3\" data-x=\"0\" data-y=\"3\" data-db-index=\"3\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"Engerix-B&lt;br&gt;(paediatric formulation)&lt;br&gt;hepatitis B\" data-order=\"Engerix-B&lt;br&gt;(paediatric formulation)&lt;br&gt;hepatitis B\" >Engerix-B<br>(paediatric formulation)<br>hepatitis B <\/td><td data-cell-id=\"B3\" data-x=\"1\" data-y=\"3\" data-db-index=\"3\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"&lt; 20 years\" data-order=\"&lt; 20 years\" >< 20 years <\/td><td data-cell-id=\"C3\" data-x=\"2\" data-y=\"3\" data-db-index=\"3\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"0.5 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" data-order=\"0.5 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" >0.5 mL<br>(10 \u00b5g)<br>IM <\/td><td data-cell-id=\"D3\" data-x=\"3\" data-y=\"3\" data-db-index=\"3\" class=\"color-3d5567 htCenter bg-eccdfc\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 4\u20136 months between doses 1 &amp; 3*\" data-order=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 4\u20136 months between doses 1 &amp; 3*\" data-colspan=\"1\" data-rowspan=\"2\" >3 doses,<br>minimum 1 month between doses 1 & 2,<br>minimum 4\u20136 months between doses 1 & 3* <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A4\" data-x=\"0\" data-y=\"4\" data-db-index=\"4\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"H-B-Vax II&lt;br&gt;(paediatric formulation)&lt;br&gt;hepatitis B\" data-order=\"H-B-Vax II&lt;br&gt;(paediatric formulation)&lt;br&gt;hepatitis B\" >H-B-Vax II<br>(paediatric formulation)<br>hepatitis B <\/td><td data-cell-id=\"B4\" data-x=\"1\" data-y=\"4\" data-db-index=\"4\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"&lt; 20 years\" data-order=\"&lt; 20 years\" >< 20 years <\/td><td data-cell-id=\"C4\" data-x=\"2\" data-y=\"4\" data-db-index=\"4\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"0.5 mL&lt;br&gt;(5 \u00b5g)&lt;br&gt;IM\" data-order=\"0.5 mL&lt;br&gt;(5 \u00b5g)&lt;br&gt;IM\" >0.5 mL<br>(5 \u00b5g)<br>IM <\/td><td data-cell-id=\"D4\" data-x=\"3\" data-y=\"4\" data-db-index=\"4\" class=\"color-3d5567 htCenter bg-eccdfc\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A5\" data-x=\"0\" data-y=\"5\" data-db-index=\"5\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"Engerix-B&lt;br&gt;(adult formulation)&lt;br&gt;hepatitis B\" data-order=\"Engerix-B&lt;br&gt;(adult formulation)&lt;br&gt;hepatitis B\" >Engerix-B<br>(adult formulation)<br>hepatitis B <\/td><td data-cell-id=\"B5\" data-x=\"1\" data-y=\"5\" data-db-index=\"5\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"\u2265 20 years^\" data-order=\"\u2265 20 years^\" >\u2265 20 years^ <\/td><td data-cell-id=\"C5\" data-x=\"2\" data-y=\"5\" data-db-index=\"5\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"1.0 mL&lt;br&gt;(20 \u00b5g)&lt;br&gt;IM\" data-order=\"1.0 mL&lt;br&gt;(20 \u00b5g)&lt;br&gt;IM\" >1.0 mL<br>(20 \u00b5g)<br>IM <\/td><td data-cell-id=\"D5\" data-x=\"3\" data-y=\"5\" data-db-index=\"5\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 4\u20136 months between doses 1 &amp; 3*\" data-order=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 4\u20136 months between doses 1 &amp; 3*\" >3 doses,<br>minimum 1 month between doses 1 & 2,<br>minimum 4\u20136 months between doses 1 & 3* <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A6\" data-x=\"0\" data-y=\"6\" data-db-index=\"6\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"H-B-Vax II&lt;br&gt;(adult formulation)&lt;br&gt;hepatitis B\" data-order=\"H-B-Vax II&lt;br&gt;(adult formulation)&lt;br&gt;hepatitis B\" >H-B-Vax II<br>(adult formulation)<br>hepatitis B <\/td><td data-cell-id=\"B6\" data-x=\"1\" data-y=\"6\" data-db-index=\"6\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"\u2265 20 years^\" data-order=\"\u2265 20 years^\" >\u2265 20 years^ <\/td><td data-cell-id=\"C6\" data-x=\"2\" data-y=\"6\" data-db-index=\"6\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"1.0 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" data-order=\"1.0 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" >1.0 mL<br>(10 \u00b5g)<br>IM <\/td><td data-cell-id=\"D6\" data-x=\"3\" data-y=\"6\" data-db-index=\"6\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 4\u20136 months between doses 1 &amp; 3\" data-order=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 4\u20136 months between doses 1 &amp; 3\" >3 doses,<br>minimum 1 month between doses 1 & 2,<br>minimum 4\u20136 months between doses 1 & 3 <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A7\" data-x=\"0\" data-y=\"7\" data-db-index=\"7\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"H-B-Vax II&lt;br&gt;(dialysis formulation)&lt;br&gt;hepatitis B\" data-order=\"H-B-Vax II&lt;br&gt;(dialysis formulation)&lt;br&gt;hepatitis B\" >H-B-Vax II<br>(dialysis formulation)<br>hepatitis B <\/td><td data-cell-id=\"B7\" data-x=\"1\" data-y=\"7\" data-db-index=\"7\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"\u2265 20 years\" data-order=\"\u2265 20 years\" >\u2265 20 years <\/td><td data-cell-id=\"C7\" data-x=\"2\" data-y=\"7\" data-db-index=\"7\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"1.0 mL&lt;br&gt;(40 \u00b5g)&lt;br&gt;IM\" data-order=\"1.0 mL&lt;br&gt;(40 \u00b5g)&lt;br&gt;IM\" >1.0 mL<br>(40 \u00b5g)<br>IM <\/td><td data-cell-id=\"D7\" data-x=\"3\" data-y=\"7\" data-db-index=\"7\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 6 months between doses 1 &amp; 3\" data-order=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt;minimum 6 months between doses 1 &amp; 3\" >3 doses,<br>minimum 1 month between doses 1 & 2,<br>minimum 6 months between doses 1 & 3 <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A8\" data-x=\"0\" data-y=\"8\" data-db-index=\"8\" class=\"htCenter color-ffffff bold bg-7ac79b\" data-cell-type=\"text\" data-original-value=\"Combination vaccines\" data-order=\"Combination vaccines\" data-colspan=\"4\" data-rowspan=\"1\" >Combination vaccines <\/td><td data-cell-id=\"B8\" data-x=\"1\" data-y=\"8\" data-db-index=\"8\" class=\"color-ffffff bold bg-7ac79b htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"C8\" data-x=\"2\" data-y=\"8\" data-db-index=\"8\" class=\"color-ffffff bold bg-7ac79b htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"D8\" data-x=\"3\" data-y=\"8\" data-db-index=\"8\" class=\"color-ffffff bold bg-7ac79b htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A9\" data-x=\"0\" data-y=\"9\" data-db-index=\"9\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"Infanrix hexa&lt;br&gt;OR&lt;br&gt;Vaxelis &lt;br&gt;DTPa, polio, hepatitis B, Hib\" data-order=\"Infanrix hexa&lt;br&gt;OR&lt;br&gt;Vaxelis &lt;br&gt;DTPa, polio, hepatitis B, Hib\" >Infanrix hexa<br>OR<br>Vaxelis <br>DTPa, polio, hepatitis B, Hib <\/td><td data-cell-id=\"B9\" data-x=\"1\" data-y=\"9\" data-db-index=\"9\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"\u2265 6 weeks\" data-order=\"\u2265 6 weeks\" >\u2265 6 weeks <\/td><td data-cell-id=\"C9\" data-x=\"2\" data-y=\"9\" data-db-index=\"9\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"0.5 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" data-order=\"0.5 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" >0.5 mL<br>(10 \u00b5g)<br>IM <\/td><td data-cell-id=\"D9\" data-x=\"3\" data-y=\"9\" data-db-index=\"9\" class=\"color-3d5467 htCenter bg-eccdfc\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between dose 1 &amp; 2,&lt;br&gt;minimum 2 months between dose 2 &amp; 3&lt;sup&gt;#\" data-order=\"3 doses,&lt;br&gt;minimum 1 month between dose 1 &amp; 2,&lt;br&gt;minimum 2 months between dose 2 &amp; 3&lt;sup&gt;#\" >3 doses,<br>minimum 1 month between dose 1 & 2,<br>minimum 2 months between dose 2 & 3<sup># <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A10\" data-x=\"0\" data-y=\"10\" data-db-index=\"10\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"Twinrix Junior (360\/10)&lt;br&gt;hepatitis A and B\" data-order=\"Twinrix Junior (360\/10)&lt;br&gt;hepatitis A and B\" >Twinrix Junior (360\/10)<br>hepatitis A and B <\/td><td data-cell-id=\"B10\" data-x=\"1\" data-y=\"10\" data-db-index=\"10\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"1\u2013 &lt;16 years\" data-order=\"1\u2013 &lt;16 years\" >1\u2013 <16 years <\/td><td data-cell-id=\"C10\" data-x=\"2\" data-y=\"10\" data-db-index=\"10\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"0.5 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" data-order=\"0.5 mL&lt;br&gt;(10 \u00b5g)&lt;br&gt;IM\" >0.5 mL<br>(10 \u00b5g)<br>IM <\/td><td data-cell-id=\"D10\" data-x=\"3\" data-y=\"10\" data-db-index=\"10\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2&lt;br&gt;minimum 6 months between doses 1 &amp; 3 \" data-order=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2&lt;br&gt;minimum 6 months between doses 1 &amp; 3 \" >3 doses,<br>minimum 1 month between doses 1 & 2<br>minimum 6 months between doses 1 & 3 <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A11\" data-x=\"0\" data-y=\"11\" data-db-index=\"11\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"Twinrix (720\/20)&lt;br&gt;hepatitis A and B\" data-order=\"Twinrix (720\/20)&lt;br&gt;hepatitis A and B\" data-colspan=\"1\" data-rowspan=\"2\" >Twinrix (720\/20)<br>hepatitis A and B <\/td><td data-cell-id=\"B11\" data-x=\"1\" data-y=\"11\" data-db-index=\"11\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"1\u2013 &lt;16 years \" data-order=\"1\u2013 &lt;16 years \" >1\u2013 <16 years <\/td><td data-cell-id=\"C11\" data-x=\"2\" data-y=\"11\" data-db-index=\"11\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"1.0 mL&lt;br&gt;(20 \u00b5g)&lt;br&gt;IM\" data-order=\"1.0 mL&lt;br&gt;(20 \u00b5g)&lt;br&gt;IM\" data-colspan=\"1\" data-rowspan=\"2\" >1.0 mL<br>(20 \u00b5g)<br>IM <\/td><td data-cell-id=\"D11\" data-x=\"3\" data-y=\"11\" data-db-index=\"11\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"2 doses,&lt;br&gt;minimum 6 months apart&lt;sup&gt;\u03a9&lt;sup&gt;\" data-order=\"2 doses,&lt;br&gt;minimum 6 months apart&lt;sup&gt;\u03a9&lt;sup&gt;\" >2 doses,<br>minimum 6 months apart<sup>\u03a9<sup><\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A12\" data-x=\"0\" data-y=\"12\" data-db-index=\"12\" class=\"color-ffffff bold htCenter bg-3d5467\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"B12\" data-x=\"1\" data-y=\"12\" data-db-index=\"12\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"\u2265 16 years \" data-order=\"\u2265 16 years \" >\u2265 16 years <\/td><td data-cell-id=\"C12\" data-x=\"2\" data-y=\"12\" data-db-index=\"12\" class=\"color-3d5567 htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"D12\" data-x=\"3\" data-y=\"12\" data-db-index=\"12\" class=\"color-3d5467 htCenter\" data-cell-type=\"text\" data-original-value=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt; minimum 6 months between doses 1 &amp; 3*\" data-order=\"3 doses,&lt;br&gt;minimum 1 month between doses 1 &amp; 2,&lt;br&gt; minimum 6 months between doses 1 &amp; 3*\" >3 doses,<br>minimum 1 month between doses 1 & 2,<br> minimum 6 months between doses 1 & 3* <\/td><\/tr><\/tbody><\/table><!-- \/#supsystic-table-127.supsystic-table --><\/div><!-- \/.supsystic-tables-wrap --><!-- Tables Generator by Supsystic --><!-- Version:1.12.0 --><!-- http:\/\/supsystic.com\/ --><a title=\"WordPress Tables Plugin\" style=\"display:none;\" href=\"https:\/\/supsystic.com\/plugins\/wordpress-data-table-plugin\/?utm_medium=love_link\" target=\"_blank\">WordPress Tables Plugin<\/a>\n\t\t<\/div>\n\t<\/div>\n<div class=\"uncode_text_column\" ><p>* <span class=\"TrackedChange SCXW180422431 BCX0\"><span class=\"TextRun SCXW180422431 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"auto\"><span class=\"NormalTextRun CommentHighlightClicked SCXW180422431 BCX0\">Refer<\/span><\/span><\/span><span class=\"TrackedChange SCXW180422431 BCX0\"><span class=\"TextRun SCXW180422431 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"auto\"><span class=\"NormalTextRun CommentHighlightClicked SCXW180422431 BCX0\"> to Australian Immunisation Handbook for advice on <a href=\"https:\/\/immunisationhandbook.health.gov.au\/node\/443\" target=\"_blank\" rel=\"noopener\">accelerated schedules for those at imminent risk of exposure to hepatitis B<\/a>.<br \/>\n^ <span class=\"NormalTextRun SCXW84598326 BCX0\">Adolescents aged 11\u201315 years can receive a 2-dose schedule of <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW84598326 BCX0\">Engerix<\/span><span class=\"NormalTextRun SCXW84598326 BCX0\">-B adult formulation or HB-Vax II adult formulation, given 6 months apart as an alternate <\/span><span class=\"NormalTextRun SCXW84598326 BCX0\">schedule.<br \/>\n# Infants vaccinated overseas who received a dose at birth, 1\u20132 months\u00a0 and &gt; 6 months are considered fully vaccinated (birth dose is considered as a valid dose 1, no need to complete a 4th dose).<br \/>\n<span class=\"TextRun SCXW28777446 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW28777446 BCX0\">\u03a9 Do not use this schedule if individual is at imminent risk of hepatitis B exposure (e.g. close contact).<\/span><\/span><br \/>\n<a class=\"box purple\" name=\"purple\"><\/a> shaded boxes indicate NIP-scheduled vaccines.<\/span><\/span><\/span><\/span><\/p>\n<h4>Interchangeability of brands<\/h4>\n<p><span data-contrast=\"auto\">I<\/span><span data-contrast=\"auto\">nfanrix<\/span> <span data-contrast=\"auto\">hexa<\/span><span data-contrast=\"auto\"> and <\/span><span data-contrast=\"auto\">Vaxelis<\/span> <span data-contrast=\"auto\">can <\/span><span data-contrast=\"auto\">be used interchangeably<\/span><span data-contrast=\"auto\"> to complete a vaccine course.<\/span><\/p>\n<p><span data-contrast=\"auto\">Switching brands between Engerix B and H-B-Vax II to complete a vaccine course is not recommended<\/span><span data-contrast=\"auto\"> due to the different processes utilised to manufacture these vaccines. If the brand required to complete an already commenced course in unavailable, adults are recommended to receive 2 doses of the corresponding paediatric vaccine simultaneously (ensuring they are injected 2.5 cm apart when using the same limb).\u00a0Refer to <a href=\"https:\/\/www.health.gov.au\/sites\/default\/files\/atagi_clinical_advice_-_hep_b.pdf\" target=\"_blank\" rel=\"noopener\">Updated ATAGI clinical advice regarding alternatives during supply shortage of the adult formulations of hepatitis B vaccines<\/a> for more information.<\/span><\/p>\n<h4>Side effects<\/h4>\n<p><span class=\"TextRun SCXW120280569 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW120280569 BCX0\">Common side effects<\/span><span class=\"NormalTextRun SCXW120280569 BCX0\"> following vaccination i<\/span><span class=\"NormalTextRun SCXW120280569 BCX0\">nclude<\/span> <span class=\"NormalTextRun SCXW120280569 BCX0\">irritability<\/span><span class=\"NormalTextRun SCXW120280569 BCX0\">, drowsiness, <\/span><a href=\"https:\/\/mvec.mcri.edu.au\/references\/injection-site-reactions\/\"><span class=\"NormalTextRun CommentStart CommentHighlightPipeRest CommentHighlightRest SCXW120280569 BCX0\">injection site<\/span><span class=\"NormalTextRun CommentHighlightRest SCXW120280569 BCX0\"> pain<\/span><span class=\"NormalTextRun CommentHighlightPipeRest SCXW120280569 BCX0\">, <\/span><span class=\"NormalTextRun SCXW120280569 BCX0\">redness<\/span><span class=\"NormalTextRun SCXW120280569 BCX0\"> and swelling<\/span><\/a><span class=\"NormalTextRun SCXW120280569 BCX0\">,<\/span><span class=\"NormalTextRun SCXW120280569 BCX0\"> and low-grade fever<\/span><span class=\"NormalTextRun SCXW120280569 BCX0\">, nausea and general aches and pains.<\/span><\/span><\/p>\n<h3>Hepatitis B serology<\/h3>\n<p><span class=\"TextRun SCXW174921523 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW174921523 BCX0\">Performing serology following hepatitis B vaccination is not routinely recommended, however may be indicated in some circumstances such as for:<\/span><\/span><\/p>\n<ul>\n<li><span data-contrast=\"none\">those at risk of severe complications of hepatitis B (e.g. people who have HIV , people with pre-existing liver disease)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">sexual partners or household contacts of people living with hepatitis B<\/span><span data-ccp-props=\"{&quot;134233117&quot;:true,&quot;134233118&quot;:true,&quot;201341983&quot;:0,&quot;335557856&quot;:16777215,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li><span data-contrast=\"none\">those with impaired renal function<\/span><\/li>\n<li><span data-contrast=\"auto\">infants born to mothers who are chronically infected with HBV.<\/span><\/li>\n<\/ul>\n<p>I<span data-contrast=\"none\">t is important to note that serology may be less reliable when conducted more than 4 to 8 weeks post the last dose of vaccination. This is because circulating anti-HBs levels decline over time even when immune memory remains, meaning results are not a reliable indicator of immunity. The exception to this is in i<\/span>nfants born to mothers chronically infected with hepatitis B; serology should be performed 3-12 months after completion of the infant schedule (and no younger than 9 months of age) to avoid detecting maternal antibodies and HBIG (hepatitis B immunoglobulin) given at birth.<\/p>\n<p><strong>Table 2: Interpretation of hepatitis B serology and actions required\u00a0<\/strong><\/p>\n<\/div>\n\t<div class=\"wpb_raw_code wpb_raw_html \" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<style type=\"text\/css\" id=\"supsystic-table-132_94812-css\">#supsystic-table-132_wrapper table { border-collapse: collapse; }#supsystic-table-132_wrapper table.stripe tbody tr.even { }#supsystic-table-132_wrapper table.stripe.order-column tbody tr > .sorting_1 { }#supsystic-table-132_wrapper table.hover tbody tr:hover { }#supsystic-table-132_wrapper table.stripe.order-column tbody tr.even > .sorting_1 { }#supsystic-table-132_wrapper table.order-column tbody tr > .sorting_1 { }#supsystic-table-132_wrapper table.hover.order-column tbody tr:hover > .sorting_1 { }#supsystic-table-132_wrapper tbody td { background-color: inherit; }\n<\/style>\n<div class=\"supsystic-table-loader spinner\"style=\"background-color:#000000\"><\/div><div id=\"supsystic-table-132_94812\" class=\"supsystic-tables-wrap \" style=\" width:100%; visibility: hidden; \" data-table-width-fixed=\"100%\" data-table-width-mobile=\"100%\" ><table id=\"supsystic-table-132\" class=\"supsystic-table paragraphMode border stripe lightboxImg cell-border\" data-id=\"132\" data-view-id=\"132_94812\" data-title=\"Hep B serology 4\u20138w post-vaccine immunocompetent\" data-currency-format=\"$1,000.00\" data-percent-format=\"10.00%\" data-date-format=\"DD.MM.YYYY\" data-time-format=\"HH:mm\" data-features=\"[&quot;after_table_loaded_script&quot;]\" data-search-value=\"\" data-loader-icon-name=\"default\" data-loader-icon-items=\"0\" data-loader-color=\"#000000\" data-processing-bg=\"#ffffff\" data-processing-color=\"#000000\" data-lightbox-img=\"\" data-head-rows-count=\"1\" data-pagination-length=\"50,100,All\" data-auto-index=\"off\" data-searching-settings=\"{&quot;columnSearchPosition&quot;:&quot;bottom&quot;,&quot;minChars&quot;:&quot;0&quot;}\" data-lang=\"default\" data-override=\"{&quot;emptyTable&quot;:&quot;&quot;,&quot;info&quot;:&quot;&quot;,&quot;infoEmpty&quot;:&quot;&quot;,&quot;infoFiltered&quot;:&quot;&quot;,&quot;lengthMenu&quot;:&quot;&quot;,&quot;search&quot;:&quot;&quot;,&quot;previous&quot;:&quot;&quot;,&quot;next&quot;:&quot;&quot;,&quot;zeroRecords&quot;:&quot;&quot;,&quot;exportLabel&quot;:&quot;&quot;,&quot;file&quot;:&quot;default&quot;}\" data-merged=\"[]\" data-responsive-mode=\"2\" data-from-history=\"0\" ><thead><tr><th class=\"\" style=\"width:15%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:15%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:; padding: 0 !important;\"><\/th><\/tr><\/thead><tbody><tr style=\"height:37px\" ><td data-cell-id=\"A1\" data-x=\"0\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Result\" data-order=\"Result\" style=\"min-width: 15%; width: 15%;\" >Result <\/td><td data-cell-id=\"B1\" data-x=\"1\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Outcome\" data-order=\"Outcome\" style=\"min-width: 15%; width: 15%;\" >Outcome <\/td><td data-cell-id=\"C1\" data-x=\"2\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Action required\" data-order=\"Action required\" style=\"min-width: 31.681%; width: 31.681%;\" >Action required <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A2\" data-x=\"0\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"anti-HBs \u2265 10 m IU\/mL\" data-order=\"anti-HBs \u2265 10 m IU\/mL\" >anti-HBs \u2265 10 m IU\/mL <\/td><td data-cell-id=\"B2\" data-x=\"1\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"immune\" data-order=\"immune\" >immune <\/td><td data-cell-id=\"C2\" data-x=\"2\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"no further action required\" data-order=\"no further action required\" >no further action required <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A3\" data-x=\"0\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"anti-HBs &lt; 10 m IU\/mL\" data-order=\"anti-HBs &lt; 10 m IU\/mL\" >anti-HBs < 10 m IU\/mL <\/td><td data-cell-id=\"B3\" data-x=\"1\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"non-immune\" data-order=\"non-immune\" >non-immune <\/td><td data-cell-id=\"C3\" data-x=\"2\" data-y=\"3\" data-db-index=\"3\" class=\"htLeft\" data-cell-type=\"text\" data-original-value=\"1. administer single age-appropriate dose of vaccine (4&lt;sup&gt;th&lt;\/sup&gt; dose)&lt;br&gt;2. check anti-HBs 4 weeks later&lt;br&gt;- if anti-HBs \u2265 10 m IU\/mL, no further action required&lt;br&gt;- if anti-HBs &lt; 10 m IU\/mL, investigate possibility of HBV infection by ordering HBsAg and Anti-HBc blood test&lt;br&gt;- if no infection, follow MVEC&#039;s pathway for hepatitis B non-responders (detailed below in the section: Recommendations for specific populations)\" data-order=\"1. administer single age-appropriate dose of vaccine (4&lt;sup&gt;th&lt;\/sup&gt; dose)&lt;br&gt;2. check anti-HBs 4 weeks later&lt;br&gt;- if anti-HBs \u2265 10 m IU\/mL, no further action required&lt;br&gt;- if anti-HBs &lt; 10 m IU\/mL, investigate possibility of HBV infection by ordering HBsAg and Anti-HBc blood test&lt;br&gt;- if no infection, follow MVEC&#039;s pathway for hepatitis B non-responders (detailed below in the section: Recommendations for specific populations)\" >1. administer single age-appropriate dose of vaccine (4<sup>th<\/sup> dose)<br>2. check anti-HBs 4 weeks later<br>- if anti-HBs \u2265 10 m IU\/mL, no further action required<br>- if anti-HBs < 10 m IU\/mL, investigate possibility of HBV infection by ordering HBsAg and Anti-HBc blood test<br>- if no infection, follow MVEC's pathway for hepatitis B non-responders (detailed below in the section: Recommendations for specific populations) <\/td><\/tr><\/tbody><\/table><!-- \/#supsystic-table-132.supsystic-table --><\/div><!-- \/.supsystic-tables-wrap --><!-- Tables Generator by Supsystic --><!-- Version:1.12.0 --><!-- http:\/\/supsystic.com\/ --><a title=\"WordPress Tables Plugin\" style=\"display:none;\" href=\"https:\/\/supsystic.com\/plugins\/wordpress-data-table-plugin\/?utm_medium=love_link\" target=\"_blank\">WordPress Tables Plugin<\/a>\n\t\t<\/div>\n\t<\/div>\n<div class=\"uncode_text_column\" ><p>Further guidance can be found at <a href=\"https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccine-preventable-diseases\/hepatitis-b#laboratory-diagnosis\" target=\"_blank\" rel=\"noopener\">The Australian Immunisation Handbook: Hepatitis B; Laboratory diagnosis<\/a>.<\/p>\n<h2>Recommendations for specific populations<\/h2>\n<p>\n<\/div><div id=\"mpc_accordion-686a3c64d385401\" class=\"mpc-accordion mpc-init mpc-transition accordion-tab\" ><ul class=\"mpc-accordion__content\"><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-566a3c64d3853e7\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>Infants born to mothers known to be HBV positive<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">Infants born to mothers known to have chronic hepatitis B must receive:<\/span><\/p>\n<ul>\n<li><span data-contrast=\"none\">a birth dose of monovalent hepatitis B vaccine<\/span><\/li>\n<li><span data-contrast=\"none\">hepatitis B immunoglobulin (HBIG).<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">These are recommended, and ideally administered on the day of birth (preferably within 12 hours), at the same time, in separate thighs. HBIG needs to be administered within 48 hours after birth (efficacy is significantly reduced if administration is delayed &gt; 48 hours after birth) and the vaccine up to 7 days after birth. The routine scheduled 3 dose course of hepatitis B vaccine should also be completed at 6 weeks, 4 months and 6 months (as per the NIP).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335557856&quot;:16777215,&quot;335559685&quot;:-540,&quot;335559737&quot;:0,&quot;335559738&quot;:270,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<p>If these precautions are followed it is safe for the infant to be <a href=\"https:\/\/mvec.mcri.edu.au\/references\/breastfeeding-and-immunisations\/\">breastfed<\/a>.<\/p>\n<p><span data-contrast=\"none\">The infant should have serology performed 3 to 12 months post the 6-month dose of hepatitis B vaccine (and no earlier than 9 months of age). <\/span><\/p>\n<p><span data-contrast=\"none\">Refer to the <\/span><a href=\"https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccine-preventable-diseases\/hepatitis-b#other-groups\"><span data-contrast=\"none\">Immunisation Handbook: Hepatitis B, recommendations for other groups<\/span><\/a><span data-contrast=\"none\">\u00a0for detailed guidance.<\/span><\/p>\n<\/div><\/div><\/div><\/li><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-566a3c64d3853e7\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>People with impaired renal function<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">People with impaired renal function (defined as chronic kidney disease 4-5, GFR &lt; 30ml\/min +\/- requiring dialysis) are at increased risk of hepatitis B infection. This is complicated by this patient cohort having a diminished immune response to hepatitis B vaccination. Whilst the cause of this suboptimal response is not completely understood, it has been established that the earlier a patient is vaccinated in the disease progression, the better the response and more long-term protection they will have.<\/span><\/p>\n<p><span data-contrast=\"none\">MVEC recommends using the combination hepatitis A and B vaccine, Twinrix (720\/20) in this patient group (see Table 3). There is <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20630640\" target=\"_blank\" rel=\"noopener\">evidence to suggest<\/a> that using this vaccine can enhance seroconversion. It also has the added benefit of providing <a href=\"https:\/\/mvec.mcri.edu.au\/references\/hepatitis-a\/\">hepatitis A<\/a> protection. If immune response to hepatitis B remains sub-optimal following the vaccination recommendations in Table 3, please refer to the below information on hepatitis B non-responders in this section.<\/span><\/p>\n<p><strong>Table 3: <span class=\"NormalTextRun SCXW233674379 BCX0\" data-ccp-charstyle=\"Strong\">Recommended vaccine schedule for those with renal impairment using combined hepatitis A and B vaccine (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW233674379 BCX0\" data-ccp-charstyle=\"Strong\">Twinrix<\/span><span class=\"NormalTextRun SCXW233674379 BCX0\" data-ccp-charstyle=\"Strong\"> (720\/20))<\/span><\/strong><\/p>\n<\/div>\n\t<div class=\"wpb_raw_code wpb_raw_html \" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<style type=\"text\/css\" id=\"supsystic-table-133_78874-css\">#supsystic-table-133_wrapper table { border-collapse: collapse; }#supsystic-table-133_wrapper table.stripe tbody tr.even { }#supsystic-table-133_wrapper table.stripe.order-column tbody tr > .sorting_1 { }#supsystic-table-133_wrapper table.hover tbody tr:hover { }#supsystic-table-133_wrapper table.stripe.order-column tbody tr.even > .sorting_1 { }#supsystic-table-133_wrapper table.order-column tbody tr > .sorting_1 { }#supsystic-table-133_wrapper table.hover.order-column tbody tr:hover > .sorting_1 { }#supsystic-table-133_wrapper tbody td { background-color: inherit; }\n<\/style>\n<div class=\"supsystic-table-loader spinner\"style=\"background-color:#000000\"><\/div><div id=\"supsystic-table-133_78874\" class=\"supsystic-tables-wrap \" style=\" width:100%; visibility: hidden; \" data-table-width-fixed=\"100%\" data-table-width-mobile=\"100%\" ><table id=\"supsystic-table-133\" class=\"supsystic-table paragraphMode border stripe lightboxImg cell-border\" data-id=\"133\" data-view-id=\"133_78874\" data-title=\"Recommended schedule for those with renal impairment combined hepA&amp;amp;B\" data-currency-format=\"$1,000.00\" data-percent-format=\"10.00%\" data-date-format=\"DD.MM.YYYY\" data-time-format=\"HH:mm\" data-features=\"[&quot;after_table_loaded_script&quot;]\" data-search-value=\"\" data-loader-icon-name=\"default\" data-loader-icon-items=\"0\" data-loader-color=\"#000000\" data-processing-bg=\"#ffffff\" data-processing-color=\"#000000\" data-lightbox-img=\"\" data-head-rows-count=\"1\" data-pagination-length=\"50,100,All\" data-auto-index=\"off\" data-searching-settings=\"{&quot;columnSearchPosition&quot;:&quot;bottom&quot;,&quot;minChars&quot;:&quot;0&quot;}\" data-lang=\"default\" data-override=\"{&quot;emptyTable&quot;:&quot;&quot;,&quot;info&quot;:&quot;&quot;,&quot;infoEmpty&quot;:&quot;&quot;,&quot;infoFiltered&quot;:&quot;&quot;,&quot;lengthMenu&quot;:&quot;&quot;,&quot;search&quot;:&quot;&quot;,&quot;previous&quot;:&quot;&quot;,&quot;next&quot;:&quot;&quot;,&quot;zeroRecords&quot;:&quot;&quot;,&quot;exportLabel&quot;:&quot;&quot;,&quot;file&quot;:&quot;default&quot;}\" data-merged=\"[{&quot;row&quot;:2,&quot;col&quot;:0,&quot;rowspan&quot;:2,&quot;colspan&quot;:1,&quot;removed&quot;:false}]\" data-responsive-mode=\"2\" data-from-history=\"0\" ><thead><tr><th class=\"\" style=\"width:15%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:15%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:; padding: 0 !important;\"><\/th><\/tr><\/thead><tbody><tr style=\"height:37px\" ><td data-cell-id=\"A1\" data-x=\"0\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Age at diagnosis of disease\" data-order=\"Age at diagnosis of disease\" style=\"min-width: 15%; width: 15%;\" >Age at diagnosis of disease <\/td><td data-cell-id=\"B1\" data-x=\"1\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Twinrix (720\/20)*\" data-order=\"Twinrix (720\/20)*\" style=\"min-width: 15%; width: 15%;\" >Twinrix (720\/20)* <\/td><td data-cell-id=\"C1\" data-x=\"2\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Serology required\" data-order=\"Serology required\" style=\"min-width: 34.1595%; width: 34.1595%;\" >Serology required <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A2\" data-x=\"0\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"&lt; 12 months\" data-order=\"&lt; 12 months\" >< 12 months <\/td><td data-cell-id=\"B2\" data-x=\"1\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"2 doses, 6 months apart&lt;br&gt;(commence vaccine course at \u2265 12 months)\" data-order=\"2 doses, 6 months apart&lt;br&gt;(commence vaccine course at \u2265 12 months)\" >2 doses, 6 months apart<br>(commence vaccine course at \u2265 12 months) <\/td><td data-cell-id=\"C2\" data-x=\"2\" data-y=\"2\" data-db-index=\"2\" class=\"htLeft\" data-cell-type=\"text\" data-original-value=\"- at diagnosis&lt;br&gt;- 1 month after 2&lt;sup&gt;nd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 7)&lt;br&gt;- every 12 months thereafter\" data-order=\"- at diagnosis&lt;br&gt;- 1 month after 2&lt;sup&gt;nd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 7)&lt;br&gt;- every 12 months thereafter\" >- at diagnosis<br>- 1 month after 2<sup>nd<\/sup> dose of Twinrix (720\/20) (month 7)<br>- every 12 months thereafter <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A3\" data-x=\"0\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"\u2265 12 months\" data-order=\"\u2265 12 months\" data-colspan=\"1\" data-rowspan=\"2\" >\u2265 12 months <\/td><td data-cell-id=\"B3\" data-x=\"1\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"if baseline anti-HBs titre \u2265 10 m IU\/mL at diagnosis:&lt;br&gt;2 doses, 6 months apart\" data-order=\"if baseline anti-HBs titre \u2265 10 m IU\/mL at diagnosis:&lt;br&gt;2 doses, 6 months apart\" >if baseline anti-HBs titre \u2265 10 m IU\/mL at diagnosis:<br>2 doses, 6 months apart <\/td><td data-cell-id=\"C3\" data-x=\"2\" data-y=\"3\" data-db-index=\"3\" class=\"htLeft\" data-cell-type=\"text\" data-original-value=\"- at diagnosis&lt;br&gt;- 1 month after 2&lt;sup&gt;nd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 7)&lt;br&gt;- every 12 months thereafter\" data-order=\"- at diagnosis&lt;br&gt;- 1 month after 2&lt;sup&gt;nd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 7)&lt;br&gt;- every 12 months thereafter\" >- at diagnosis<br>- 1 month after 2<sup>nd<\/sup> dose of Twinrix (720\/20) (month 7)<br>- every 12 months thereafter <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A4\" data-x=\"0\" data-y=\"4\" data-db-index=\"4\" class=\"\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"B4\" data-x=\"1\" data-y=\"4\" data-db-index=\"4\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"if baseline anti-HBs titre &lt; 10 m IU\/mL at diagnosis:&lt;br&gt;3 doses, 1 week between doses 1 &amp; 2, 5 months between doses 2 &amp; 3\" data-order=\"if baseline anti-HBs titre &lt; 10 m IU\/mL at diagnosis:&lt;br&gt;3 doses, 1 week between doses 1 &amp; 2, 5 months between doses 2 &amp; 3\" >if baseline anti-HBs titre < 10 m IU\/mL at diagnosis:<br>3 doses, 1 week between doses 1 & 2, 5 months between doses 2 & 3 <\/td><td data-cell-id=\"C4\" data-x=\"2\" data-y=\"4\" data-db-index=\"4\" class=\"htLeft\" data-cell-type=\"text\" data-original-value=\"- at diagnosis&lt;br&gt;- 1 month after 2&lt;sup&gt;nd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 2)&lt;br&gt;- 1 month after 3&lt;sup&gt;rd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 7)&lt;br&gt;- every 12 months thereafter\" data-order=\"- at diagnosis&lt;br&gt;- 1 month after 2&lt;sup&gt;nd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 2)&lt;br&gt;- 1 month after 3&lt;sup&gt;rd&lt;\/sup&gt; dose of Twinrix (720\/20) (month 7)&lt;br&gt;- every 12 months thereafter\" >- at diagnosis<br>- 1 month after 2<sup>nd<\/sup> dose of Twinrix (720\/20) (month 2)<br>- 1 month after 3<sup>rd<\/sup> dose of Twinrix (720\/20) (month 7)<br>- every 12 months thereafter <\/td><\/tr><\/tbody><\/table><!-- \/#supsystic-table-133.supsystic-table --><\/div><!-- \/.supsystic-tables-wrap --><!-- Tables Generator by Supsystic --><!-- Version:1.12.0 --><!-- http:\/\/supsystic.com\/ --><a title=\"WordPress Tables Plugin\" style=\"display:none;\" href=\"https:\/\/supsystic.com\/plugins\/wordpress-data-table-plugin\/?utm_medium=love_link\" target=\"_blank\">WordPress Tables Plugin<\/a>\n\t\t<\/div>\n\t<\/div>\n<div class=\"uncode_text_column\" ><p>* <span class=\"NormalTextRun SpellingErrorV2Themed SCXW226485143 BCX0\">Twinrix<\/span><span class=\"NormalTextRun SCXW226485143 BCX0\"> (720\/20) is a combination hepatitis A and B vaccine. It <\/span><span class=\"NormalTextRun SCXW226485143 BCX0\">contains<\/span><span class=\"NormalTextRun SCXW226485143 BCX0\"> 720 ELISA units of hepatitis A virus and 20mcg of hepatitis B surface antigen protein. Each dose is 1.0 mL given intramuscularly.<\/span><\/p>\n<\/div><\/div><\/div><\/li><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-566a3c64d3853e7\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>Hepatitis B non-responders<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">A non-responder to hepatitis B vaccination is any person with a documented age-appropriate vaccine history, who has an anti-HBs level of &lt;10 m lU\/mL 4 to 8 weeks following the final vaccine dose.<\/span><\/p>\n<p><span data-contrast=\"none\">Recommendations for how to promote seroconversion in this population vary with different studies. MVEC recommends the following immunisation pathway for hepatitis B non-responders: <a href=\"https:\/\/mvec.mcri.edu.au\/wp-content\/uploads\/2014\/07\/MVEC-hepatitis-B-non-responders_-December-2024.pdf\" target=\"_blank\" rel=\"noopener\">MVEC pathway for hepatitis B non-responders \u2265 12-months of age (December 2024)<\/a>.<\/span><\/p>\n<p><span data-contrast=\"none\">Persistent non-responders should be informed of their immune status and advised to minimise the risk of exposure.<\/span><\/p>\n<p><span data-contrast=\"none\">Hepatitis B immunoglobulin (HBIG) may be given to non-immune persons within 72 hours of exposure to prevent infection. Refer to <\/span><a href=\"https:\/\/immunisationhandbook.health.gov.au\/resources\/tables\/table-post-exposure-prophylaxis-for-non-immune-people-exposed-to-a-source-that-is-positive-for-hepatitis-b-surface-antigen-or-has-an-unknown-status\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">The Australian Immunisation Handbook: Table: Post-exposure prophylaxis for non-immune people exposed to a source that is positive for hepatitis B surface antigen or has an unknown status<\/span><\/a> <span data-contrast=\"none\">for more information.<\/span><\/p>\n<\/div><\/div><\/div><\/li><\/ul><\/div><div class=\"uncode_text_column\" ><\/p>\n<h2>Resources<\/h2>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><a href=\"https:\/\/immunisationhandbook.health.gov.au\/vaccine-preventable-diseases\/hepatitis-b\" target=\"_blank\" rel=\"noopener noreferrer\">Australian Immunisation Handbook: Hepatitis B<\/a><\/li>\n<li><a href=\"https:\/\/www.betterhealth.vic.gov.au\/health\/healthyliving\/hepatitis-b-immunisation\" target=\"_blank\" rel=\"noopener\">Better Health Channel: Hepatitis B<\/a><\/li>\n<li><a href=\"https:\/\/hepatitisb.org.au\/\" target=\"_blank\" rel=\"noopener\"><span class=\"NormalTextRun SCXW186682701 BCX0\">B<\/span><span class=\"NormalTextRun SCXW186682701 BCX0\"> Positive: A Guide for Primary Care Providers<\/span><\/a><\/li>\n<li><a href=\"https:\/\/mvec.mcri.edu.au\/wp-content\/uploads\/2014\/07\/MVEC-hepatitis-B-non-responders_-December-2024.pdf\" target=\"_blank\" rel=\"noopener\">MVEC pathway for hepatitis B non-responders \u2265 12-months of age (December 2024)<\/a><\/li>\n<li><a href=\"http:\/\/www.mvec.vic.edu.au\/immunisation-references\/solid-organ-transplant-recipient\/\" rel=\"noopener noreferrer\">MVEC: Solid organ transplant recipient<\/a><\/li>\n<li><a href=\"http:\/\/www.mvec.vic.edu.au\/immunisation-references\/preterm-infant-immunisation\/\" rel=\"noopener noreferrer\">MVEC: Preterm infant immunisation<\/a><\/li>\n<li><a href=\"https:\/\/mvec.mcri.edu.au\/references\/breastfeeding-and-immunisations\/\">MVEC: Breastfeeding and vaccines<\/a><\/li>\n<li><a href=\"https:\/\/www.rch.org.au\/clinicalguide\/guideline_index\/Needle_stick_injury\/\" target=\"_blank\" rel=\"noopener\">RCH clinical practice guidelines: Needle stick injury<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20630640\" target=\"_blank\" rel=\"noopener noreferrer\">Tung J, Carlisle E, Smieja M, Kim PT, Lee CH. A Randomized Clinical Trial of Immunization With Combined Hepatitis A and B Versus Hepatitis B Alone for Hepatitis B Seroprotection in Hemodialysis Patients. Am J Kidney Dis. 2010;56(4):713-9.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11894838\" target=\"_blank\" rel=\"noopener noreferrer\">Playford EG, Hogan PG, Bansal AS, Harrison K, Drummond D, Looke DF, Whitby M. Intradermal recombinant hepatitis B vaccine for healthcare workers who fail to respond to intramuscular vaccine. Infection Control and Hospital Epidemiology 2002 Feb;23(2):87-90<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n<\/div><div class=\"uncode_text_column\" ><\/p>\n<div class=\"reviewedSection\">\n<p><strong>Authors:<\/strong> Nigel Crawford (Director, SAEFVIC, Murdoch Children\u2019s Research Institute) and Rachael McGuire (SAEFVIC Research Nurse, Murdoch Children&#8217;s Research Institute)<\/p>\n<p><strong>Reviewed by:<\/strong> Rachael McGuire (Education Nurse Coordinator, Melbourne Vaccine Education Centre), Katie Butler (Education Nurse Coordinator, Melbourne Vaccine Education Centre), Nigel Crawford (Director, SAEFVIC and MVEC, Murdoch Children\u2019s Research Institute) and Laura Voss (SAEFVIC Research Nurse, Murdoch Children&#8217;s Research Institute)<\/p>\n<p><strong>Date:<\/strong> December 2024<\/p>\n<p>Materials in this section are updated as new information and vaccines become available. The Melbourne Vaccine Education Centre (MVEC) staff regularly reviews materials for accuracy.<\/p>\n<p>You should not consider the information on this site to be specific, professional medical advice for your personal health or for your family&#8217;s personal health. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult a healthcare professional.<\/p>\n<\/div>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/div><script id=\"script-row-unique-0\" data-row=\"script-row-unique-0\" type=\"text\/javascript\" class=\"vc_controls\">UNCODE.initRow(document.getElementById(\"row-unique-0\"));<\/script><\/div><\/div><\/div>\n<\/div>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":"","_wp_rev_ctl_limit":""},"first_letter":[16],"class_list":["post-7175","references","type-references","status-publish","hentry","first_letter-h"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hepatitis B - The Melbourne Vaccine Education Centre (MVEC)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mvec.mcri.edu.au\/hi\/\u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e-\u0926\u0947\u0902-\u0938\u0902\u0926\u0930\u094d\u092d\/\u0939\u0947\u092a\u0947\u091f\u093e\u0907\u091f\u093f\u0938-\u092c\u0940\/\" \/>\n<meta property=\"og:locale\" content=\"hi_IN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatitis B - 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