{"id":715,"date":"2014-08-07T11:44:24","date_gmt":"2014-08-07T01:44:24","guid":{"rendered":"http:\/\/www.mvec.vic.edu.au\/?page_id=715"},"modified":"2024-12-03T12:55:08","modified_gmt":"2024-12-03T01:55:08","slug":"live-attenuated-vaccines-and-immunoglobulins-or-blood-products","status":"publish","type":"references","link":"https:\/\/mvec.mcri.edu.au\/vi\/references\/live-attenuated-vaccines-and-immunoglobulins-or-blood-products\/","title":{"rendered":"Live\u2011attenuated vaccines and immunoglobulins or blood products"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div data-parent=\"true\" class=\"vc_row row-container\" id=\"row-unique-0\"><div class=\"row single-top-padding single-bottom-padding one-h-padding full-width row-parent\"><div class=\"wpb_row row-inner\"><div class=\"wpb_column pos-top pos-center align_left column_parent col-lg-12 single-internal-gutter\"><div class=\"uncol style-light\"  ><div class=\"uncoltable\"><div class=\"uncell no-block-padding\" ><div class=\"uncont\" ><div class=\"uncode_text_column\" ><\/p>\n<h2>Background<\/h2>\n<p><span class=\"TextRun SCXW169390144 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW169390144 BCX0\">Transfusions<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\"> of <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">n<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">ormal human immunoglobulin <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">(<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW169390144 BCX0\">NHIg<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">) <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">or <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">other <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">donated <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">blood <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">product<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">s<\/span> <span class=\"NormalTextRun SCXW169390144 BCX0\">may be<\/span> <span class=\"NormalTextRun SCXW169390144 BCX0\">used in<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\"> the<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\"> treatment <\/span><span class=\"NormalTextRun SCXW169390144 BCX0\">of<\/span><span class=\"NormalTextRun SCXW169390144 BCX0\"> certain medical conditions, including:<\/span><\/span><\/p>\n<ul>\n<li><span data-contrast=\"none\"><a href=\"https:\/\/mvec.mcri.edu.au\/references\/immune-thrombocytopenia-itp\/\">ITP<\/a> or <a href=\"https:\/\/mvec.mcri.edu.au\/references\/kawasaki-disease-and-immunisation\/\">Kawasaki disease<\/a><\/span><\/li>\n<li><span data-contrast=\"none\">traumatic injuries<\/span><\/li>\n<li><span data-contrast=\"none\">haematological conditions<\/span><\/li>\n<li><span data-contrast=\"none\">post<\/span><span data-contrast=\"none\">\u2011<\/span><span data-contrast=\"none\">exposure to some infectious diseases (e.g. <a href=\"https:\/\/mvec.mcri.edu.au\/references\/tetanus-prone-wounds-management\/\">tetanus<\/a>, <a href=\"https:\/\/mvec.mcri.edu.au\/references\/rabies\/\">rabies<\/a> and <a href=\"https:\/\/mvec.mcri.edu.au\/references\/hepatitis-b\/\">hepatitis B<\/a>)<\/span><\/li>\n<li><span data-contrast=\"none\">as an adjunct to cancer treatments or surgery.<\/span><\/li>\n<\/ul>\n<p><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">These products <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">contain<\/span> <span class=\"NormalTextRun SCXW45504611 BCX0\">low levels of <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">antibodies<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">,<\/span> <span class=\"NormalTextRun SCXW45504611 BCX0\">passed on from <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">the donor<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\"> to the recipient<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">. <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">The donated antibodies<\/span> <span class=\"NormalTextRun SCXW45504611 BCX0\">can <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">provide <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">r<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">ecipients <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">with <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">short<\/span><\/span><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">term<\/span> <span class=\"NormalTextRun SCXW45504611 BCX0\">protection against <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">certain<\/span> <span class=\"NormalTextRun SCXW45504611 BCX0\">vaccine<\/span><\/span><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">preventable diseases (VPDs)<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">.<\/span> <span class=\"NormalTextRun SCXW45504611 BCX0\">H<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">owever<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">,<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\"> vaccination is still <\/span><span class=\"NormalTextRun SCXW45504611 BCX0\">required<\/span><span class=\"NormalTextRun SCXW45504611 BCX0\"> for long<\/span><\/span><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW45504611 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW45504611 BCX0\">term protection.<\/span><\/span><\/p>\n<p><span data-contrast=\"none\">Circulating donated antibodies can inhibit the recipient\u2019s own immune response to certain injected <\/span><span data-contrast=\"none\"><a href=\"https:\/\/mvec.mcri.edu.au\/references\/vaccine-platforms\/\">live-attenuated vaccines<\/a>, if the vaccines are administered too soon after the transfusion.<\/span><\/p>\n<h2>Recommendations<\/h2>\n<p><span data-contrast=\"none\">There are prescribed intervals between the transfusion of NHIg and\/or a blood product and the administration of certain vaccines. This is to allow enough time for any donated antibodies to clear,\u00a0 optimising long<\/span><span data-contrast=\"none\">\u2011<\/span><span data-contrast=\"none\">term effectiveness of the vaccine. The interval length depends on the type of product and the volume\/dose transfused.<\/span><\/p>\n<p><span data-contrast=\"none\">The following recommendations are aimed at ensuring the adequate immune response is achieved. They do not reflect concerns related to safety or adverse events following vaccine administration.<\/span><\/p>\n<p><span data-contrast=\"none\">It is important to note that inactivated (non<\/span><span data-contrast=\"none\">\u2011<\/span><span data-contrast=\"none\">live) vaccines can be safely administered at any time during or following the administration of NHIg and\/or blood products.<\/span><\/p>\n<p><strong><span class=\"TextRun MacChromeBold SCXW156204586 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun CommentStart SCXW156204586 BCX0\">Table 1: <\/span><span class=\"NormalTextRun SCXW156204586 BCX0\">Live<\/span><\/span><span class=\"TextRun MacChromeBold SCXW156204586 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW156204586 BCX0\">\u2011<\/span><\/span><span class=\"TextRun MacChromeBold SCXW156204586 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW156204586 BCX0\">attenuated vaccines and the action <\/span><span class=\"NormalTextRun SCXW156204586 BCX0\">required<\/span><span class=\"NormalTextRun SCXW156204586 BCX0\"> when blood products previously given<\/span><\/span><\/strong><\/p>\n<\/div>\n\t<div class=\"wpb_raw_code wpb_raw_html \" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<style type=\"text\/css\" id=\"supsystic-table-128_54931-css\">#supsystic-table-128_wrapper table { border-collapse: collapse; }#supsystic-table-128_wrapper table.stripe tbody tr.even { }#supsystic-table-128_wrapper table.stripe.order-column tbody tr > .sorting_1 { }#supsystic-table-128_wrapper table.hover tbody tr:hover { }#supsystic-table-128_wrapper table.stripe.order-column tbody tr.even > .sorting_1 { }#supsystic-table-128_wrapper table.order-column tbody tr > .sorting_1 { }#supsystic-table-128_wrapper table.hover.order-column tbody tr:hover > .sorting_1 { }#supsystic-table-128_wrapper tbody td { background-color: inherit; }\n<\/style>\n<div class=\"supsystic-table-loader spinner\"style=\"background-color:#000000\"><\/div><div id=\"supsystic-table-128_54931\" class=\"supsystic-tables-wrap \" style=\" width:100%; visibility: hidden; \" data-table-width-fixed=\"100%\" data-table-width-mobile=\"100%\" ><table id=\"supsystic-table-128\" class=\"supsystic-table paragraphMode border stripe lightboxImg cell-border\" data-id=\"128\" data-view-id=\"128_54931\" data-title=\"Live-attenuated vaccines and blood products\" data-currency-format=\"$1,000.00\" data-percent-format=\"10.00%\" data-date-format=\"DD.MM.YYYY\" data-time-format=\"HH:mm\" data-features=\"[&quot;after_table_loaded_script&quot;]\" data-search-value=\"\" data-lightbox-img=\"\" data-head-rows-count=\"1\" data-pagination-length=\"50,100,All\" data-auto-index=\"off\" data-searching-settings=\"{&quot;columnSearchPosition&quot;:&quot;bottom&quot;,&quot;minChars&quot;:&quot;0&quot;}\" data-lang=\"default\" data-override=\"{&quot;emptyTable&quot;:&quot;&quot;,&quot;info&quot;:&quot;&quot;,&quot;infoEmpty&quot;:&quot;&quot;,&quot;infoFiltered&quot;:&quot;&quot;,&quot;lengthMenu&quot;:&quot;&quot;,&quot;search&quot;:&quot;&quot;,&quot;previous&quot;:&quot;&quot;,&quot;next&quot;:&quot;&quot;,&quot;zeroRecords&quot;:&quot;&quot;,&quot;exportLabel&quot;:&quot;&quot;,&quot;file&quot;:&quot;default&quot;}\" data-merged=\"[]\" data-responsive-mode=\"2\" data-from-history=\"0\" ><thead><tr><th class=\"\" style=\"width:; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:; padding: 0 !important;\"><\/th><\/tr><\/thead><tbody><tr style=\"height:37px\" ><td data-cell-id=\"A1\" data-x=\"0\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Vaccine\" data-order=\"Vaccine\" style=\"min-width:34.1595%; width:34.1595%;\" >Vaccine <\/td><td data-cell-id=\"B1\" data-x=\"1\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Disease\" data-order=\"Disease\" style=\"min-width:34.1595%; width:34.1595%;\" >Disease <\/td><td data-cell-id=\"C1\" data-x=\"2\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Action required\" data-order=\"Action required\" style=\"min-width:31.681%; width:31.681%;\" >Action required <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A2\" data-x=\"0\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"BCG\" data-order=\"BCG\" >BCG <\/td><td data-cell-id=\"B2\" data-x=\"1\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"tuberculosis\" data-order=\"tuberculosis\" >tuberculosis <\/td><td data-cell-id=\"C2\" data-x=\"2\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"no interval needed\" data-order=\"no interval needed\" >no interval needed <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A3\" data-x=\"0\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Rotarix*\/Rotateq*\" data-order=\"Rotarix*\/Rotateq*\" >Rotarix*\/Rotateq* <\/td><td data-cell-id=\"B3\" data-x=\"1\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"rotavirus\" data-order=\"rotavirus\" >rotavirus <\/td><td data-cell-id=\"C3\" data-x=\"2\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"no interval needed\" data-order=\"no interval needed\" >no interval needed <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A4\" data-x=\"0\" data-y=\"4\" data-db-index=\"4\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Priorix\" data-order=\"Priorix\" >Priorix <\/td><td data-cell-id=\"B4\" data-x=\"1\" data-y=\"4\" data-db-index=\"4\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"meales, mumps and rubella\" data-order=\"meales, mumps and rubella\" >meales, mumps and rubella <\/td><td data-cell-id=\"C4\" data-x=\"2\" data-y=\"4\" data-db-index=\"4\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"interval recommended^\" data-order=\"interval recommended^\" >interval recommended^ <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A5\" data-x=\"0\" data-y=\"5\" data-db-index=\"5\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Varilrix\" data-order=\"Varilrix\" >Varilrix <\/td><td data-cell-id=\"B5\" data-x=\"1\" data-y=\"5\" data-db-index=\"5\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"varicella (chickenpox)\" data-order=\"varicella (chickenpox)\" >varicella (chickenpox) <\/td><td data-cell-id=\"C5\" data-x=\"2\" data-y=\"5\" data-db-index=\"5\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"interval recommended^\" data-order=\"interval recommended^\" >interval recommended^ <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A6\" data-x=\"0\" data-y=\"6\" data-db-index=\"6\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Priorix-tetra\" data-order=\"Priorix-tetra\" >Priorix-tetra <\/td><td data-cell-id=\"B6\" data-x=\"1\" data-y=\"6\" data-db-index=\"6\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"measles, mumps, rubella and varicella\" data-order=\"measles, mumps, rubella and varicella\" >measles, mumps, rubella and varicella <\/td><td data-cell-id=\"C6\" data-x=\"2\" data-y=\"6\" data-db-index=\"6\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"interval recommended^\" data-order=\"interval recommended^\" >interval recommended^ <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A7\" data-x=\"0\" data-y=\"7\" data-db-index=\"7\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Imojev\" data-order=\"Imojev\" >Imojev <\/td><td data-cell-id=\"B7\" data-x=\"1\" data-y=\"7\" data-db-index=\"7\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Japanese encephalitis\" data-order=\"Japanese encephalitis\" >Japanese encephalitis <\/td><td data-cell-id=\"C7\" data-x=\"2\" data-y=\"7\" data-db-index=\"7\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"interval recommended^&lt;sup&gt;#&lt;\/sup&gt;\" data-order=\"interval recommended^&lt;sup&gt;#&lt;\/sup&gt;\" >interval recommended^<sup>#<\/sup><\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A8\" data-x=\"0\" data-y=\"8\" data-db-index=\"8\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Stamaril\" data-order=\"Stamaril\" >Stamaril <\/td><td data-cell-id=\"B8\" data-x=\"1\" data-y=\"8\" data-db-index=\"8\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"yellow fever\" data-order=\"yellow fever\" >yellow fever <\/td><td data-cell-id=\"C8\" data-x=\"2\" data-y=\"8\" data-db-index=\"8\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"no interval needed\" data-order=\"no interval needed\" >no interval needed <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A9\" data-x=\"0\" data-y=\"9\" data-db-index=\"9\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Vivotif*\" data-order=\"Vivotif*\" >Vivotif* <\/td><td data-cell-id=\"B9\" data-x=\"1\" data-y=\"9\" data-db-index=\"9\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"typhoid\" data-order=\"typhoid\" >typhoid <\/td><td data-cell-id=\"C9\" data-x=\"2\" data-y=\"9\" data-db-index=\"9\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"no interval needed\" data-order=\"no interval needed\" >no interval needed <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A10\" data-x=\"0\" data-y=\"10\" data-db-index=\"10\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"Zostavax\" data-order=\"Zostavax\" >Zostavax <\/td><td data-cell-id=\"B10\" data-x=\"1\" data-y=\"10\" data-db-index=\"10\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"zoster (shingles)\" data-order=\"zoster (shingles)\" >zoster (shingles) <\/td><td data-cell-id=\"C10\" data-x=\"2\" data-y=\"10\" data-db-index=\"10\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"no interval needed&lt;sup&gt;#&lt;\/sup&gt;\" data-order=\"no interval needed&lt;sup&gt;#&lt;\/sup&gt;\" >no interval needed<sup>#<\/sup><\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A11\" data-x=\"0\" data-y=\"11\" data-db-index=\"11\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"ACAM2000\" data-order=\"ACAM2000\" >ACAM2000 <\/td><td data-cell-id=\"B11\" data-x=\"1\" data-y=\"11\" data-db-index=\"11\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"mpox\" data-order=\"mpox\" >mpox <\/td><td data-cell-id=\"C11\" data-x=\"2\" data-y=\"11\" data-db-index=\"11\" class=\"htCenter\" data-cell-type=\"text\" data-original-value=\"use JYNNEOS (MVA-BN)\" data-order=\"use JYNNEOS (MVA-BN)\" >use JYNNEOS (MVA-BN) <\/td><\/tr><\/tbody><\/table><!-- \/#supsystic-table-128.supsystic-table --><\/div><!-- \/.supsystic-tables-wrap --><!-- Tables Generator by Supsystic --><!-- Version:1.11.2 --><!-- http:\/\/supsystic.com\/ --><a title=\"WordPress Tables Plugin\" style=\"display:none;\" href=\"https:\/\/supsystic.com\/plugins\/wordpress-data-table-plugin\/?utm_medium=love_link\" target=\"_blank\">WordPress Tables Plugin<\/a>\n\t\t<\/div>\n\t<\/div>\n<div class=\"uncode_text_column\" ><p><span class=\"TextRun SCXW69773096 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">* oral vaccine<br \/>\n<\/span><\/span><span class=\"TextRun SCXW69773096 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">^ Refer to t<\/span><\/span><span class=\"TextRun SCXW69773096 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">he <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">Immunisation<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\"> Handbook guidance on <\/span><a href=\"https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccination-for-special-risk-groups\/vaccination-for-people-who-have-recently-received-normal-human-immunoglobulin-and-other-blood-products\" target=\"_blank\" rel=\"noopener\"><span class=\"NormalTextRun CommentStart CommentHighlightPipeRest CommentHighlightRest SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">Vaccination for people who have recently received normal human immunoglobulin and other blood products<\/span><\/a><\/span><span class=\"TextRun SCXW69773096 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun CommentHighlightPipeRest SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\"> for recomm<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">ended <\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">timeframes<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">.<\/span><\/span><span class=\"LineBreakBlob BlobObject DragDrop SCXW69773096 BCX0\"><span class=\"SCXW69773096 BCX0\">\u00a0<\/span><br class=\"SCXW69773096 BCX0\" \/><\/span><span class=\"TextRun SCXW69773096 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\"># <\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">A<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">n alternat<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">ive,<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\"> inactivated vaccine is available and may be considered<\/span><span class=\"NormalTextRun SCXW69773096 BCX0\" data-ccp-parastyle=\"heading 1\">.<\/span><\/span><\/p>\n<h2><span class=\"TextRun MacChromeBold SCXW129637878 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW129637878 BCX0\">Patients receiving regular red blood cell transfusions<\/span><\/span><\/h2>\n<p><span class=\"TextRun SCXW243789513 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243789513 BCX0\">Patients <\/span><span class=\"NormalTextRun SCXW243789513 BCX0\">requiring<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> regular red<\/span> <span class=\"NormalTextRun SCXW243789513 BCX0\">blood cell transfusions for a chronic <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243789513 BCX0\">haematologic<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> condition (<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\">e.g.<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> transfusion<\/span><\/span><span class=\"TextRun SCXW243789513 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243789513 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW243789513 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243789513 BCX0\">dependent <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243789513 BCX0\">thalassaemia<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\">, sickle cell disease, inherited chronic <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243789513 BCX0\">haemolytic<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW243789513 BCX0\">anaemias<\/span> <span class=\"NormalTextRun SCXW243789513 BCX0\">and<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> inherited bone marrow failure syndromes) are unlikely to achieve a transfusion<\/span><\/span><span class=\"TextRun SCXW243789513 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243789513 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW243789513 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW243789513 BCX0\">free period long enough to allow <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW243789513 BCX0\">immunisation<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> according to the<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> standard<\/span><span class=\"NormalTextRun SCXW243789513 BCX0\"> recommendations.<\/span><\/span><\/p>\n<p><span class=\"NormalTextRun SCXW142090285 BCX0\">There is limited direct data on which to base decisions <\/span><span class=\"NormalTextRun SCXW142090285 BCX0\">for<\/span><span class=\"NormalTextRun SCXW142090285 BCX0\"> this group<\/span><span class=\"NormalTextRun SCXW142090285 BCX0\">.<\/span><\/p>\n<p><span class=\"TextRun SCXW252899550 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW252899550 BCX0\">For p<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">atients requiring chronic red <\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">blood <\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">cell transfusions, who will not achieve a transfusion free period of more than 3<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\"> to <\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">6 months in the <\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">foreseeable future<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">, <\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">MVEC <\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">recommend<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">s<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\"> live<\/span><\/span><span class=\"TextRun SCXW252899550 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW252899550 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW252899550 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW252899550 BCX0\">attenuated vaccines be administered per the <\/span><a href=\"https:\/\/www.health.gov.au\/resources\/publications\/national-immunisation-program-schedule?language=en\" target=\"_blank\" rel=\"noopener\"><span class=\"NormalTextRun CommentStart CommentHighlightPipeRest CommentHighlightRest SCXW252899550 BCX0\">National <\/span><span class=\"NormalTextRun SpellingErrorV2Themed CommentHighlightRest SCXW252899550 BCX0\">Immunisation<\/span><span class=\"NormalTextRun CommentHighlightRest SCXW252899550 BCX0\"> Program (NIP)<\/span><\/a><span class=\"NormalTextRun CommentHighlightPipeRest SCXW252899550 BCX0\">, despite being within the usually recommended deferral period pos<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\">t<\/span><\/span><span class=\"TextRun SCXW252899550 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW252899550 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW252899550 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW252899550 BCX0\">transfusion. Please refer to your <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW252899550 BCX0\">haematologist<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\"> or an <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW252899550 BCX0\">immunisation<\/span><span class=\"NormalTextRun SCXW252899550 BCX0\"> specialist for specific advice.<\/span><\/span><\/p>\n<p><span data-contrast=\"none\">This recommendation is based on:<\/span><\/p>\n<ul>\n<li><span data-contrast=\"none\">the expectation that the vaccines will still provide protection in a number of patients (albeit potentially lower than that in the general population)<\/span><\/li>\n<li><span data-contrast=\"none\">the lack of any additional safety concerns associated with administration of the vaccine in this setting<\/span><\/li>\n<li><span data-contrast=\"none\">the alternative being indefinite deferral of immunisation.<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">Patients should be informed of the potential for reduced effectiveness of the vaccine.<\/span><\/p>\n<p><span data-contrast=\"none\">A protocol for optimal timing of immunisation (in relation to blood transfusion, serological testing post immunisation and re<\/span><span data-contrast=\"none\">\u2011<\/span><span data-contrast=\"none\">immunisation when there is no evidence of immunity) may help to improve response rates. <\/span><span data-contrast=\"none\">MVEC has <\/span><span data-contrast=\"none\">produced<\/span><span data-contrast=\"none\"> a <\/span><a href=\"https:\/\/mvec.mcri.edu.au\/wp-content\/uploads\/2020\/07\/Live-attenuated-vaccines-in-patients-receiving-regular-red-blood-cell-transfusions_protocol-July-2020.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">protocol<\/span><span data-contrast=\"none\"> for MMR and varicella vaccines in patients receiving regular red blood cell transfusions<\/span><\/a><span data-contrast=\"none\">.<\/span><\/p>\n<h2>Documentation<\/h2>\n<p><span class=\"NormalTextRun SCXW78425581 BCX0\">People who<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> have received <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW78425581 BCX0\">NHIg<\/span> <span class=\"NormalTextRun SCXW78425581 BCX0\">and\/<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">or<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> other<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> blood products<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> and are <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">scheduled <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">for <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">upcoming <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">vaccine<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">s<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> should have a temporary exemption documented on <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">the <\/span><a href=\"https:\/\/mvec.mcri.edu.au\/references\/australian-immunisation-register\/\"><span class=\"NormalTextRun CommentStart CommentHighlightPipeRest CommentHighlightRest SCXW78425581 BCX0\">A<\/span><span class=\"NormalTextRun CommentHighlightRest SCXW78425581 BCX0\">ustralian <\/span><span class=\"NormalTextRun SpellingErrorV2Themed CommentHighlightRest SCXW78425581 BCX0\">I<\/span><span class=\"NormalTextRun SpellingErrorV2Themed CommentHighlightRest SCXW78425581 BCX0\">mmunisation<\/span> <span class=\"NormalTextRun CommentHighlightRest SCXW78425581 BCX0\">R<\/span><span class=\"NormalTextRun CommentHighlightRest SCXW78425581 BCX0\">egister (AIR<\/span><span class=\"NormalTextRun CommentHighlightPipeRest SCXW78425581 BCX0\">)<\/span><\/a><span class=\"NormalTextRun SCXW78425581 BCX0\">.<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> This <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">will ensure that <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">any<\/span> <a href=\"https:\/\/mvec.mcri.edu.au\/references\/mandatory-vaccine-directions-in-victoria\/\"><span class=\"NormalTextRun CommentHighlightRest SCXW78425581 BCX0\">\u201cno jab, no pay\u201d and \u201cno jab, no play\u201d<\/span><\/a><span class=\"NormalTextRun CommentHighlightPipeRest SCXW78425581 BCX0\"> entitlements <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">are not affected<\/span> <span class=\"NormalTextRun SCXW78425581 BCX0\">a<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">nd <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">will <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW78425581 BCX0\">minimise<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\"> the likelihood of vaccin<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">e administration <\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">error<\/span><span class=\"NormalTextRun SCXW78425581 BCX0\">s.<\/span><\/p>\n<h2>Commonly asked questions<\/h2>\n<p>\n<\/div><div id=\"mpc_accordion-286a2db35a5bebd\" class=\"mpc-accordion mpc-init mpc-transition accordion-tab\" ><ul class=\"mpc-accordion__content\"><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-786a2db35a5be9b\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>Do previous live\u2011attenuated vaccines need to be repeated following a transfusion?<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><\/p>\n<p aria-level=\"3\"><span class=\"TextRun SCXW6940251 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW6940251 BCX0\">Receiving a blood product at any stage after having already received live<\/span><\/span><span class=\"TextRun SCXW6940251 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW6940251 BCX0\">\u2011<\/span><\/span><span class=\"TextRun SCXW6940251 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW6940251 BCX0\">attenuated vaccines does not <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW6940251 BCX0\">jeopa<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW6940251 BCX0\">r<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW6940251 BCX0\">dise<\/span><span class=\"NormalTextRun SCXW6940251 BCX0\"> the <\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">effectiveness of the <\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">immune response to <\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">those <\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">vaccine<\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">s<\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">. There<\/span><span class=\"NormalTextRun SCXW6940251 BCX0\"> are no safety concerns and <\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">no need to repeat <\/span><span class=\"NormalTextRun SCXW6940251 BCX0\">any previously given vaccines.<\/span><\/span><\/p>\n<p>\n<\/div><\/div><\/div><\/li><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-786a2db35a5be9b\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>What is the process if a vaccine is inadvertently administered too soon after receiving transfusion?<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">The patient\/family should be informed of the error using the <a href=\"https:\/\/mvec.mcri.edu.au\/references\/open-disclosure\/\">open disclosure framework<\/a> and reassured that this is not a safety concern. The inadvertently administered dose is an invalid dose and will need to be repeated (after the appropriate interval has passed) to ensure the patient is protected.<\/span><\/p>\n<p><span data-contrast=\"none\">It should also be noted in the patient records that this is considered an invalid dose and must be repeated once the appropriate interval has passed\/4 weeks after the inadvertent dose was administered (whichever is later).<\/span><\/p>\n<p><span class=\"TextRun SCXW80696838 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW80696838 BCX0\">All vaccines should be reported on AIR, whether they were intended for administration or not.<\/span><\/span><\/p>\n<\/div><\/div><\/div><\/li><\/ul><\/div><div class=\"uncode_text_column\" ><\/p>\n<h2>Resources<\/h2>\n<ul>\n<li><a href=\"https:\/\/immunisationhandbook.health.gov.au\/vaccination-for-special-risk-groups\/vaccination-for-people-who-have-recently-received-normal-human\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Australian Immunisation Handbook: Vaccination for people who have recently received normal human immunoglobulin and other blood products<\/span><\/a><\/li>\n<li><a href=\"https:\/\/transfusion.com.au\/blood_products\/components\/red_cells\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Australian Red Cross Life Blood: Red cells<\/span><\/a><\/li>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/trf.15433\" target=\"_blank\" rel=\"noopener\">Zabeida A, Lebel MH, Renaud C, Cloutier M, Robitaille N. Reevaluating immunization delays after red blood cell transfusion.\u00a0<em>Transfusion<\/em>. 2019;59(9):2806-2811. doi:10.1111\/trf.15433<\/a><\/li>\n<li><a href=\"http:\/\/www.cdc.gov\/vaccines\/hcp\/acip-recs\/general-recs\/downloads\/general-recs.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP): General Best Practice Guidelines for Immunization<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.nec.navajo-nsn.gov\/Portals\/0\/NN%20Research\/John%20Hopkins%20Publications\/1993-%20Interference%20of%20immune%20globulin%20with%20measles%20and%20rubella%20Immunization.pdf\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Siber GR, Werner BG, Halsey NA, et al. Interference of immune globulin with measles and rubella immunization. <em>J Pediatr<\/em>. 1993;122(2):204-211. doi:10.1016\/s0022-3476(06)80114-9<\/span><\/a><\/li>\n<\/ul>\n<p>\n<\/div><div class=\"uncode_text_column\" ><\/p>\n<div class=\"reviewedSection\">\n<p><strong>Authors: <\/strong>Nigel Crawford (Director, SAEFVIC, Murdoch Children\u2019s Research Institute) and\u00a0Rachael McGuire (SAEFVIC Research Nurse, Murdoch Children\u2019s Research Institute)<\/p>\n<p><strong>Reviewed by:<\/strong> Rachael McGuire (MVEC Education Nurse Coordinator) and Katie Butler (MVEC Education Nurse)<\/p>\n<p><strong>Date:<\/strong> November 2024<\/p>\n<p>Materials in this section are updated as new information and vaccines become available. The Melbourne Vaccine Education Centre (MVEC) staff regularly reviews materials for accuracy.<\/p>\n<p>You should not consider the information on this site to be specific, professional medical advice for your personal health or for your family\u2019s personal health. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult a healthcare professional.<\/p>\n<\/div>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/div><script id=\"script-row-unique-0\" data-row=\"script-row-unique-0\" type=\"text\/javascript\" class=\"vc_controls\">UNCODE.initRow(document.getElementById(\"row-unique-0\"));<\/script><\/div><\/div><\/div>\n<\/div>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":"","_wp_rev_ctl_limit":""},"first_letter":[20],"class_list":["post-715","references","type-references","status-publish","hentry","first_letter-l"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Live\u2011attenuated vaccines and immunoglobulins or blood products - The Melbourne Vaccine Education Centre (MVEC)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mvec.mcri.edu.au\/vi\/nguoi-gioi-thieu\/live-attenuated-vaccines-and-immunoglobulins-or-blood-products\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Live\u2011attenuated vaccines and immunoglobulins or blood products - 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