{"id":1079,"date":"2015-07-17T15:41:58","date_gmt":"2015-07-17T05:41:58","guid":{"rendered":"http:\/\/www.mvec.vic.edu.au\/?page_id=1079"},"modified":"2025-07-10T12:07:25","modified_gmt":"2025-07-10T02:07:25","slug":"rabies","status":"publish","type":"references","link":"https:\/\/mvec.mcri.edu.au\/zh\/references\/rabies\/","title":{"rendered":"\u72c2\u72ac\u75c5"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div data-parent=\"true\" class=\"vc_row row-container\" id=\"row-unique-0\"><div class=\"row single-top-padding single-bottom-padding one-h-padding full-width row-parent\"><div class=\"wpb_row row-inner\"><div class=\"wpb_column pos-top pos-center align_left column_parent col-lg-12 single-internal-gutter\"><div class=\"uncol style-light\"  ><div class=\"uncoltable\"><div class=\"uncell no-block-padding\" ><div class=\"uncont\" ><div class=\"uncode_text_column\" ><\/p>\n<h2>What is it?<\/h2>\n<p><span class=\"TextRun SCXW266362211 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266362211 BCX0\">R<\/span><\/span><span class=\"TextRun SCXW266362211 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266362211 BCX0\">abies <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">is<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> an acute viral <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">encephalomye<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">li<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">tis<\/span> <span class=\"NormalTextRun SCXW266362211 BCX0\">(infl<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">ammatory disease of the brain and\/or spinal cord<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">)<\/span> <span class=\"NormalTextRun SCXW266362211 BCX0\">caused by infection with the rabies virus<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">, a type of lyssa<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">virus. <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">Other lyssaviruses include <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">Australian bat l<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">yssavirus<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> (ABLV<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">)<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> and the European bat lyssavirus (EBLV)<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">.<\/span> <\/span><\/p>\n<p><span class=\"TextRun SCXW266362211 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW266362211 BCX0\">Rabies is transmitted to humans via bites or scratches <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">from<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> animals infected with the virus.<\/span> <span class=\"NormalTextRun SCXW266362211 BCX0\">Infection with <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">the <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">rabies <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">virus<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">,<\/span> <span class=\"NormalTextRun SCXW266362211 BCX0\">and other lyssaviruses<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">,<\/span> <span class=\"NormalTextRun SCXW266362211 BCX0\">result<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">s<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> in <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">a<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> progressive <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">inflammation of the brain and spinal cord<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">. Without vaccination <\/span><\/span><span class=\"TrackedChange SCXW266362211 BCX0\"><span class=\"TextRun SCXW266362211 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun CommentStart SCXW266362211 BCX0\">and<\/span><\/span><\/span><span class=\"TextRun SCXW266362211 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"> <span class=\"NormalTextRun SCXW266362211 BCX0\">effective post-exposure management<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">,<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> rabies<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> is <\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">almost always<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\"> fatal<\/span><span class=\"NormalTextRun SCXW266362211 BCX0\">.<\/span><\/span><span class=\"EOP SCXW266362211 BCX0\" data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h2>What to look for<\/h2>\n<p><span data-contrast=\"none\">The incubation period of rabies is generally between 3 and 12 weeks, but the onset of symptoms has occurred as early as days after exposure or as long as 19 years later.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Early signs of infection involve non-specific symptoms, such as loss of appetite, cough, fever, headache, discomfort and fatigue, nausea and vomiting, and sore throat. There also may be discomfort, paraesthesia (prickling or itching sensation) and fasciculations (muscle twitching) at the site of the scratch or bite. A person may show signs of anxiety, confusion and agitation. These initial symptoms last 1 to 4 days. Following this, symptoms progress to:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">delirium and bizarre behaviour<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\"><span class=\"TextRun SCXW20248431 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW20248431 BCX0\">disorientation<\/span><\/span> <\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">hallucinations<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">hypersalivation, hyperthermia and hyperventilation (signs of autonomic instability)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"none\">hydrophobia (fear of water)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><span data-contrast=\"none\">paralysis<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"33\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"8\" data-aria-level=\"1\"><span data-contrast=\"none\">insomnia.<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">The disease progresses rapidly. Once clinical signs have developed, the person\u2019s neurological status will deteriorate over a period of up to 12 days, resulting in death. There is no specific treatment for rabies.<\/span><\/p>\n<h2>How is it transmitted?<\/h2>\n<p><span data-contrast=\"none\">Rabies is a zoonotic disease (spread between animals and humans). Dog species (including wolves, coyotes, foxes and jackals) are the main source of infection for humans. Skunks, raccoons, monkeys and bats can also harbour infection. <\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Human exposure occurs primarily through the scratch or deep bite of an infected animal. Transmission can also occur if saliva of an infected animal comes into direct contact with a person\u2019s mucosal surface (nose, eyes or mouth).\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The virus travels from the site of the injury to the brain by moving along nerve pathways.<\/span><\/p>\n<h2>Epidemiology<\/h2>\n<p><span data-contrast=\"none\">Rabies is found in animals on all continents of the globe except Antarctica. Australia is currently rabies free. However, ABLV has been known to occur in fruit bats and insectivorous bats.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><span data-contrast=\"none\">It is difficult to determine the disease burden in animals, due to the impracticalities of testing wild and domestic animals.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Each year, rabies infection causes approximately 59,000 human deaths worldwide, 95% of these occurring in Africa and Asia. The burden of disease in humans is higher in rural, low-income populations. Children are more likely to be infected due to their size and proximity to the ground, <\/span><span data-contrast=\"none\">being<\/span> <span data-contrast=\"none\">less likely to appreciate an animal\u2019s temperament, and their tendency <\/span><span data-contrast=\"none\">to make sudden movements or loud noises <\/span><span data-contrast=\"none\">which are intimidating to animals.\u00a0<\/span><\/p>\n<h2>Prevention<\/h2>\n<p><span data-contrast=\"none\">According to the World Health Organization, vaccinating dogs in rabies-prone regions is the most cost-effective strategy for preventing rabies in people.<\/span><\/p>\n<p><span data-contrast=\"none\">People who will be travelling to, or living in, rabies-prone regions should take preventative measures. These include:<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559682&quot;:43,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">avoiding close contact with wild and domestic animals (this is especially important for children)<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559682&quot;:43,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">not feeding, patting or playing with animals<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"43\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559682&quot;:43,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">getting vaccinated.<\/span><\/li>\n<\/ul>\n<h3>Vaccination<\/h3>\n<p><span data-contrast=\"auto\">Vaccines can be administered either before potential exposure (pre-exposure prophylaxis), or after exposure has occurred (as part of post-exposure prophylaxis).<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Pre-exposure vaccination requires fewer vaccine doses and eliminates the need for immunoglobulin if exposed (except for those who are severely immunocompromised). Immunoglobulin may be expensive and difficult to source in developing countries.\u00a0<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">There are 2 rabies vaccines available in <\/span><span data-contrast=\"none\">Australi<\/span><span data-contrast=\"auto\">a:<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"39\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;9675&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"2\"><span data-contrast=\"auto\">Verorab<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"39\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:1440,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;9675&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"2\"><span data-contrast=\"auto\">Rabipur<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Both Verorab and Rabipur are <a href=\"https:\/\/mvec.mcri.edu.au\/references\/vaccine-platforms\/\">inactivated vaccines<\/a> and can be administered via the <a href=\"https:\/\/mvec.mcri.edu.au\/references\/vaccine-administration\/\">intramuscular (IM) route or the intradermal (ID) route<\/a>.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">It is preferable but not essential to use the same brand of vaccine for the entire course.<\/span><span data-contrast=\"auto\"> If using the same brand is not possible, vaccination should not be delayed, and the alternate brand should be used.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<\/div><div id=\"mpc_accordion-426a3791c74b5bc\" class=\"mpc-accordion mpc-init mpc-transition accordion-tab\" ><ul class=\"mpc-accordion__content\"><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-666a3791c74b5a6\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>Pre-exposure prophylaxis<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">Vaccination is recommended for:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"30\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">people who work with bats<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"30\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">laboratory workers who work with live lyssaviruses<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"30\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">people travelling to, working in or moving to rabies-prone regions, based on a risk assessment with a travel medicine adviser.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<h4>Table 1: Pre-exposure prophylaxis schedule<\/h4>\n<p>\n<\/div>\n\t<div class=\"wpb_raw_code wpb_raw_html \" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<style type=\"text\/css\" id=\"supsystic-table-85_96700-css\">#supsystic-table-85_wrapper table { border-collapse: collapse; }#supsystic-table-85_wrapper table.stripe tbody tr.even { }#supsystic-table-85_wrapper table.stripe.order-column tbody tr > .sorting_1 { }#supsystic-table-85_wrapper table.hover tbody tr:hover { }#supsystic-table-85_wrapper table.stripe.order-column tbody tr.even > .sorting_1 { }#supsystic-table-85_wrapper table.order-column tbody tr > .sorting_1 { }#supsystic-table-85_wrapper table.hover.order-column tbody tr:hover > .sorting_1 { }#supsystic-table-85_wrapper tbody td { background-color: inherit; }\n<\/style>\n<div class=\"supsystic-table-loader spinner\"style=\"background-color:#000000\"><\/div><div id=\"supsystic-table-85_96700\" class=\"supsystic-tables-wrap \" style=\" width:100%; visibility: hidden; \" data-table-width-fixed=\"100%\" data-table-width-mobile=\"100%\" ><table id=\"supsystic-table-85\" class=\"supsystic-table paragraphMode border stripe lightboxImg cell-border\" data-id=\"85\" data-view-id=\"85_96700\" data-title=\"Rabies\" data-currency-format=\"$1,000.00\" data-percent-format=\"10.00%\" data-date-format=\"DD.MM.YYYY\" data-time-format=\"HH:mm\" data-features=\"[&quot;after_table_loaded_script&quot;]\" data-search-value=\"\" data-lightbox-img=\"\" data-head-rows-count=\"1\" data-pagination-length=\"50,100,All\" data-auto-index=\"off\" data-searching-settings=\"{&quot;columnSearchPosition&quot;:&quot;bottom&quot;,&quot;minChars&quot;:&quot;0&quot;}\" data-lang=\"default\" data-override=\"{&quot;emptyTable&quot;:&quot;&quot;,&quot;info&quot;:&quot;&quot;,&quot;infoEmpty&quot;:&quot;&quot;,&quot;infoFiltered&quot;:&quot;&quot;,&quot;lengthMenu&quot;:&quot;&quot;,&quot;search&quot;:&quot;&quot;,&quot;previous&quot;:&quot;&quot;,&quot;next&quot;:&quot;&quot;,&quot;zeroRecords&quot;:&quot;&quot;,&quot;exportLabel&quot;:&quot;&quot;,&quot;file&quot;:&quot;default&quot;}\" data-merged=\"[{&quot;row&quot;:1,&quot;col&quot;:0,&quot;rowspan&quot;:2,&quot;colspan&quot;:1,&quot;removed&quot;:false}]\" data-responsive-mode=\"2\" data-from-history=\"0\" ><thead><tr><th class=\"\" style=\"width:25%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:25%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:25%; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:25%; padding: 0 !important;\"><\/th><\/tr><\/thead><tbody><tr style=\"height:37px\" ><td data-cell-id=\"A1\" data-x=\"0\" data-y=\"1\" data-db-index=\"1\" class=\"bg-3d5467 color-ffffff bold htCenter\" data-cell-type=\"text\" data-original-value=\"Vaccine brand\" data-order=\"Vaccine brand\" style=\"min-width:25%; width:25%;\" >Vaccine brand <\/td><td data-cell-id=\"B1\" data-x=\"1\" data-y=\"1\" data-db-index=\"1\" class=\"bg-3d5467 color-ffffff bold htCenter\" data-cell-type=\"text\" data-original-value=\"Route&lt;br&gt;and dose\" data-order=\"Route&lt;br&gt;and dose\" style=\"min-width:25%; width:25%;\" >Route<br>and dose <\/td><td data-cell-id=\"C1\" data-x=\"2\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Standard&lt;br&gt;schedule\" data-order=\"Standard&lt;br&gt;schedule\" style=\"min-width:25%; width:25%;\" >Standard<br>schedule <\/td><td data-cell-id=\"D1\" data-x=\"3\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Accelerated schedule\" data-order=\"Accelerated schedule\" style=\"min-width:25%; width:25%;\" >Accelerated schedule <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A2\" data-x=\"0\" data-y=\"2\" data-db-index=\"2\" class=\"bg-3d5467 color-ffffff bold htCenter\" data-cell-type=\"text\" data-original-value=\"Rabipur&lt;br&gt;and&lt;br&gt;Verorab\" data-order=\"Rabipur&lt;br&gt;and&lt;br&gt;Verorab\" data-colspan=\"1\" data-rowspan=\"2\" >Rabipur<br>and<br>Verorab <\/td><td data-cell-id=\"B2\" data-x=\"1\" data-y=\"2\" data-db-index=\"2\" class=\"htCenter color-3d5567\" data-cell-type=\"text\" data-original-value=\"IM&lt;br&gt;1.0 mL for Rabipur&lt;br&gt;0.5 mL for Verorab\" data-order=\"IM&lt;br&gt;1.0 mL for Rabipur&lt;br&gt;0.5 mL for Verorab\" >IM<br>1.0 mL for Rabipur<br>0.5 mL for Verorab <\/td><td data-cell-id=\"C2\" data-x=\"2\" data-y=\"2\" data-db-index=\"2\" class=\"color-3d5567\" data-cell-type=\"text\" data-original-value=\"3 doses&lt;br&gt;(days 0, 7&lt;br&gt;and 21\u201328)\" data-order=\"3 doses&lt;br&gt;(days 0, 7&lt;br&gt;and 21\u201328)\" >3 doses<br>(days 0, 7<br>and 21\u201328) <\/td><td data-cell-id=\"D2\" data-x=\"3\" data-y=\"2\" data-db-index=\"2\" class=\"color-3d5567\" data-cell-type=\"text\" data-original-value=\"2 doses&lt;br&gt;(days 0 and 7)&lt;sup&gt;#\" data-order=\"2 doses&lt;br&gt;(days 0 and 7)&lt;sup&gt;#\" >2 doses<br>(days 0 and 7)<sup># <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A3\" data-x=\"0\" data-y=\"3\" data-db-index=\"3\" class=\"bg-3d5467 color-ffffff bold htCenter\" data-cell-type=\"text\" data-original-value=\"\" data-order=\"\" data-hide=\"true\" ><\/td><td data-cell-id=\"B3\" data-x=\"1\" data-y=\"3\" data-db-index=\"3\" class=\"htCenter color-3d5567\" data-cell-type=\"text\" data-original-value=\"ID*&lt;br&gt;0.1 mL\" data-order=\"ID*&lt;br&gt;0.1 mL\" >ID*<br>0.1 mL <\/td><td data-cell-id=\"C3\" data-x=\"2\" data-y=\"3\" data-db-index=\"3\" class=\"color-3d5567\" data-cell-type=\"text\" data-original-value=\"3 doses&lt;br&gt;(days 0, 7&lt;br&gt;and 21\u201328)\" data-order=\"3 doses&lt;br&gt;(days 0, 7&lt;br&gt;and 21\u201328)\" >3 doses<br>(days 0, 7<br>and 21\u201328) <\/td><td data-cell-id=\"D3\" data-x=\"3\" data-y=\"3\" data-db-index=\"3\" class=\"color-3d5567\" data-cell-type=\"text\" data-original-value=\"4 doses&lt;br&gt;(2 \u00d7 0.1 mL doses given at alternate sites, on day 0 and day 7)&lt;sup&gt;#^\" data-order=\"4 doses&lt;br&gt;(2 \u00d7 0.1 mL doses given at alternate sites, on day 0 and day 7)&lt;sup&gt;#^\" >4 doses<br>(2 \u00d7 0.1 mL doses given at alternate sites, on day 0 and day 7)<sup>#^ <\/td><\/tr><\/tbody><\/table><!-- \/#supsystic-table-85.supsystic-table --><\/div><!-- \/.supsystic-tables-wrap --><!-- Tables Generator by Supsystic --><!-- Version:1.11.2 --><!-- http:\/\/supsystic.com\/ --><a title=\"WordPress Tables Plugin\" style=\"display:none;\" href=\"https:\/\/supsystic.com\/plugins\/wordpress-data-table-plugin\/?utm_medium=love_link\" target=\"_blank\">WordPress Tables Plugin<\/a>\n\t\t<\/div>\n\t<\/div>\n<div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">*intradermal route is not recommended for individuals with immunocompromise, can only be administered by providers with specialist training and should not be administered to patients taking antimalarials at the time of vaccination or within 1 month of vaccination.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\"><br \/>\n<\/span><span data-contrast=\"none\">^intradermal accelerated schedules should not be used in people &gt; 50 years of age due to a lack of evidence for seroconversion.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\"><br \/>\n<\/span><span data-contrast=\"none\">#<\/span><span data-contrast=\"none\">If exposure risk continues &gt; 1 year after vaccination, refer booster dose recommendations in the table below. <\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<\/div><\/div><\/div><\/li><li class=\"mpc-accordion__item \"><div class=\"mpc-accordion-item__heading mpc-transition mpc-typography--default\"><div data-id=\"mpc_icon-666a3791c74b5a6\" class=\"mpc-icon mpc-init mpc-transition mpc-effect-fade mpc-icon-hover \"><div class=\"mpc-icon-wrap\"><i class=\"mpc-icon-part mpc-regular mpc-transition  eti eti_arrow_right-down\"><\/i><i class=\"mpc-icon-part mpc-hover mpc-transition  eti eti_arrow_left-up\"><\/i><\/div><\/div><h3>Post-exposure prophylaxis<\/h3><\/div><div class=\"mpc-accordion-item__content mpc-container\" ><div class=\"mpc-accordion-item__wrapper mpc-typography--default\"><div class=\"uncode_text_column\" ><p><span data-contrast=\"none\">There are important steps to take after a potential exposure to the rabies virus. These include: <\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"44\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">timely wound management<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"44\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">medical review (including risk assessment)<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"44\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">administration of rabies vaccine (regardless of pre-exposure vaccine history).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">Human rabies immunoglobulin is also administered in some cases. Rabies immunoglobulin provides short-term protection against the immediate development of rabies. Vaccination provides longer-term protection against the development of disease.\u00a0<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Those who have previously been vaccinated against rabies <\/span><span data-contrast=\"none\">still require post<\/span><span data-contrast=\"none\">&#8211;<\/span><span data-contrast=\"none\">exposure treatment<\/span><span data-contrast=\"none\">.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The Australian Immunisation Handbook includes 2 different post exposure prophylaxis <\/span><span data-contrast=\"none\">management algorithms. For detailed guidance, refer <\/span><span data-contrast=\"none\">to:\u00a0<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"51\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><a href=\"https:\/\/immunisationhandbook.health.gov.au\/resources\/figures\/figure-rabies-post-exposure-prophylaxis-terrestrial-animal-exposures\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Figure. Rabies post-exposure prophylaxis: terrestrial animal exposures<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:720,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259,&quot;335559991&quot;:360}\">\u00a0<\/span><\/a><\/li>\n<li data-leveltext=\"\u00b7\" data-font=\"Symbol\" data-listid=\"51\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u00b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><a href=\"https:\/\/immunisationhandbook.health.gov.au\/resources\/figures\/figure-rabies-post-exposure-prophylaxis-bat-exposures\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"auto\">Figure. Rabies post-exposure prophylaxis: bat exposures<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:720,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259,&quot;335559991&quot;:360}\">\u00a0<\/span><\/a><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">If post-exposure prophylaxis is commenced overseas (with clear documentation of an appropriate vaccine course), Australian clinicians can complete treatment in accordance with the post-exposure prophylaxis guidance in the Handbook. If there is unclear documentation or in other scenarios, consult the <\/span><a href=\"https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccine-preventable-diseases\/rabies-and-other-lyssaviruses#vaccination-after-potential-exposure-to-rabies-virus-or-other-lyssaviruses-postexposure-prophylaxis\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Immunisation Handbook <\/span><\/a><span data-contrast=\"none\">or an Infectious Diseases specialist.<\/span><\/p>\n<\/div><\/div><\/div><\/li><\/ul><\/div><div class=\"uncode_text_column\" ><\/p>\n<h3><b><span data-contrast=\"none\">Boosters and serology<\/span><\/b><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">Recommendations for vaccine boosters and serology (blood testing to check antibody levels) vary on a case-by-case basis. Individuals should seek personalised advice from their healthcare provider (e.g. immunisation provider, travel medicine adviser or other specialist consultant).<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">It is especially important for individuals in the following groups to speak with their health provider for specific advice on boosters and serology:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559685&quot;:0,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"63\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">immunocompromised individuals<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"63\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">laboratory workers who work with live lyssaviruses<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"63\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">people with ongoing exposure to bats or potentially rabid mammals.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559737&quot;:0,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:259}\">\u00a0<\/span><\/li>\n<\/ul>\n<h4><strong><span class=\"TextRun SCXW19415117 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW19415117 BCX0\">Table 2: <\/span><span class=\"NormalTextRun SCXW19415117 BCX0\">Immunisation<\/span><span class=\"NormalTextRun SCXW19415117 BCX0\"> Handbook <\/span><span class=\"NormalTextRun SCXW19415117 BCX0\">s<\/span><span class=\"NormalTextRun SCXW19415117 BCX0\">erology recommendations<\/span><\/span><\/strong><\/h4>\n<p>\n<\/div>\n\t<div class=\"wpb_raw_code wpb_raw_html \" >\n\t\t<div class=\"wpb_wrapper\">\n\t\t\t<style type=\"text\/css\" id=\"supsystic-table-89_78996-css\">#supsystic-table-89_wrapper table { border-collapse: collapse; }#supsystic-table-89_wrapper table.stripe tbody tr.even { }#supsystic-table-89_wrapper table.stripe.order-column tbody tr > .sorting_1 { }#supsystic-table-89_wrapper table.hover tbody tr:hover { }#supsystic-table-89_wrapper table.stripe.order-column tbody tr.even > .sorting_1 { }#supsystic-table-89_wrapper table.order-column tbody tr > .sorting_1 { }#supsystic-table-89_wrapper table.hover.order-column tbody tr:hover > .sorting_1 { }#supsystic-table-89_wrapper tbody td { background-color: inherit; }\n<\/style>\n<div class=\"supsystic-table-loader spinner\"style=\"background-color:#000000\"><\/div><div id=\"supsystic-table-89_78996\" class=\"supsystic-tables-wrap \" style=\" width:100%; visibility: hidden; \" data-table-width-fixed=\"100%\" data-table-width-mobile=\"100%\" ><table id=\"supsystic-table-89\" class=\"supsystic-table paragraphMode border stripe lightboxImg cell-border\" data-id=\"89\" data-view-id=\"89_78996\" data-title=\"Rabies_Serology\" data-currency-format=\"$1,000.00\" data-percent-format=\"10.00%\" data-date-format=\"DD.MM.YYYY\" data-time-format=\"HH:mm\" data-features=\"[&quot;after_table_loaded_script&quot;]\" data-search-value=\"\" data-lightbox-img=\"\" data-head-rows-count=\"1\" data-pagination-length=\"50,100,All\" data-auto-index=\"off\" data-searching-settings=\"{&quot;columnSearchPosition&quot;:&quot;bottom&quot;,&quot;minChars&quot;:&quot;0&quot;}\" data-lang=\"default\" data-override=\"{&quot;emptyTable&quot;:&quot;&quot;,&quot;info&quot;:&quot;&quot;,&quot;infoEmpty&quot;:&quot;&quot;,&quot;infoFiltered&quot;:&quot;&quot;,&quot;lengthMenu&quot;:&quot;&quot;,&quot;search&quot;:&quot;&quot;,&quot;previous&quot;:&quot;&quot;,&quot;next&quot;:&quot;&quot;,&quot;zeroRecords&quot;:&quot;&quot;,&quot;exportLabel&quot;:&quot;&quot;,&quot;file&quot;:&quot;default&quot;}\" data-merged=\"[]\" data-responsive-mode=\"2\" data-from-history=\"0\" ><thead><tr><th class=\"\" style=\"width:auto; padding: 0 !important;\"><\/th><th class=\"\" style=\"width:auto; padding: 0 !important;\"><\/th><\/tr><\/thead><tbody><tr style=\"height:37px\" ><td data-cell-id=\"A1\" data-x=\"0\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Recommended for:\" data-order=\"Recommended for:\" style=\"min-width:auto; width:auto;\" >Recommended for: <\/td><td data-cell-id=\"B1\" data-x=\"1\" data-y=\"1\" data-db-index=\"1\" class=\"color-ffffff bold bg-3d5467 htMiddle htCenter\" data-cell-type=\"text\" data-original-value=\"Timeframe:\" data-order=\"Timeframe:\" style=\"min-width:auto; width:auto;\" >Timeframe: <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A2\" data-x=\"0\" data-y=\"2\" data-db-index=\"2\" class=\"\" data-cell-type=\"text\" data-original-value=\"-Immunocompromised people&lt;br&gt;-People who received vaccination via ID route\" data-order=\"-Immunocompromised people&lt;br&gt;-People who received vaccination via ID route\" >-Immunocompromised people<br>-People who received vaccination via ID route <\/td><td data-cell-id=\"B2\" data-x=\"1\" data-y=\"2\" data-db-index=\"2\" class=\"\" data-cell-type=\"text\" data-original-value=\"2\u20134 weeks after the final dose of vaccine\" data-order=\"2\u20134 weeks after the final dose of vaccine\" >2\u20134 weeks after the final dose of vaccine <\/td><\/tr><tr style=\"height:37px\" ><td data-cell-id=\"A3\" data-x=\"0\" data-y=\"3\" data-db-index=\"3\" class=\"\" data-cell-type=\"text\" data-original-value=\"-Laboratory workers who work with live lyssaviruses\" data-order=\"-Laboratory workers who work with live lyssaviruses\" >-Laboratory workers who work with live lyssaviruses <\/td><td data-cell-id=\"B3\" data-x=\"1\" data-y=\"3\" data-db-index=\"3\" class=\"\" data-cell-type=\"text\" data-original-value=\"Every 6 months after completion of primary course or most recent booster \" data-order=\"Every 6 months after completion of primary course or most recent booster \" >Every 6 months after completion of primary course or most recent booster <\/td><\/tr><tr style=\"height:px\" ><td data-cell-id=\"A4\" data-x=\"0\" data-y=\"4\" data-db-index=\"4\" class=\"\" data-cell-type=\"text\" data-original-value=\"-People with ongoing risk of exposure to bats or potentially rabid mammals \" data-order=\"-People with ongoing risk of exposure to bats or potentially rabid mammals \" >-People with ongoing risk of exposure to bats or potentially rabid mammals <\/td><td data-cell-id=\"B4\" data-x=\"1\" data-y=\"4\" data-db-index=\"4\" class=\"\" data-cell-type=\"text\" data-original-value=\"Every 3 years after booster dose* \" data-order=\"Every 3 years after booster dose* \" >Every 3 years after booster dose* <\/td><\/tr><\/tbody><\/table><!-- \/#supsystic-table-89.supsystic-table --><\/div><!-- \/.supsystic-tables-wrap --><!-- Tables Generator by Supsystic --><!-- Version:1.11.2 --><!-- http:\/\/supsystic.com\/ --><a title=\"WordPress Tables Plugin\" style=\"display:none;\" href=\"https:\/\/supsystic.com\/plugins\/wordpress-data-table-plugin\/?utm_medium=love_link\" target=\"_blank\">WordPress Tables Plugin<\/a>\n\t\t<\/div>\n\t<\/div>\n<div class=\"uncode_text_column\" ><p><span data-contrast=\"auto\">* <\/span><span data-contrast=\"auto\">Or, receive a booster dose every 3 years without checking serology.<\/span><\/p>\n<p><span data-contrast=\"none\">A single IM booster dose is recommended for people with significant ongoing exposure risk:<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"61\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">when serology is &lt; 0.5 IU\/mL\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"61\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:&#091;8226&#093;,&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">12 months after dose 1 of primary course of vaccination (whether pre- or post-exposure) then every 3 years after first booster (<\/span><span data-contrast=\"auto\">may check serology first<\/span><span data-contrast=\"auto\">).<\/span><\/li>\n<\/ul>\n<h3><b><span data-contrast=\"none\">Precautions<\/span><\/b><\/h3>\n<p><span data-contrast=\"none\">People with anaphylaxis to egg should receive Verorab instead of Rabipur.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Peop<\/span><span data-contrast=\"none\">le with latex allergy should receive Rabipur instead of <\/span><span data-contrast=\"none\">Verorab<\/span><span data-contrast=\"none\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h3><b><span data-contrast=\"none\">Co-administration with other vaccines<\/span><\/b><\/h3>\n<p><span data-contrast=\"none\">Verorab and Rabipur can be co-administered with other vaccines, using separate injection sites.\u00a0<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Tetanus vaccination status should also be considered after a bite or scratch from an animal, see <a href=\"https:\/\/mvec.mcri.edu.au\/references\/tetanus-prone-wounds-management\/\">MVEC: Tetanus<\/a>.<\/span><span data-ccp-props=\"{&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<h3><b><span data-contrast=\"none\">Vaccine side effects<\/span><\/b><\/h3>\n<p><span data-contrast=\"none\">Common side effects following rabies vaccination include nausea, headache, injection site pain and myalgia (muscle aches).<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Due to the seriousness of disease, post exposure vaccination should never be delayed<\/span><span data-contrast=\"none\">,<\/span><span data-contrast=\"none\"> even in those who have experienced an unpleasant side effect or who have a history of allergic reactions. A specialist immunisation service should be contacted for specific advice.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<h2>Resources<\/h2>\n<ul>\n<li><a href=\"https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccine-preventable-diseases\/rabies-and-other-lyssaviruses\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Australian Immunisation Handbook guideline\u00a0<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.rch.org.au\/clinicalguide\/guideline_index\/Rabies_and_Australian_Bat_Lyssavirus_post_exposure_prophylaxis\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">RCH post-exposure Clinical Practice Guideline<\/span><\/a><\/li>\n<li><a href=\"https:\/\/immunisationhandbook.health.gov.au\/resources\/tables\/table-completing-rabies-post-exposure-prophylaxis-in-australia-that-started-overseas\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Overseas post-exposure prophylaxis guidelines<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.health.vic.gov.au\/immunisation\/ordering-vaccines\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">Ordering vaccines online<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.health.vic.gov.au\/infectious-diseases\/rabies-and-australian-bat-lyssavirus\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">DOH notification requirements<\/span><\/a><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:0}\">\u00a0<\/span><\/li>\n<\/ul>\n<p>\n<\/div><div class=\"uncode_text_column\" ><\/p>\n<div class=\"reviewedSection\">\n<p><strong>Author: <\/strong>Rachael McGuire (SAEFVIC Research Nurse, Murdoch Children&#8217;s Research Institute)<\/p>\n<p><strong><span class=\"TextRun SCXW127010942 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW127010942 BCX0\">Reviewed by: <\/span><\/span><\/strong><span class=\"TextRun SCXW127010942 BCX0\" lang=\"EN-AU\" xml:lang=\"EN-AU\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW127010942 BCX0\">Katie Butler (MVEC Education Nurse Coordinator<\/span><span class=\"NormalTextRun SCXW127010942 BCX0\">) and <\/span><span class=\"NormalTextRun SCXW127010942 BCX0\">Rachael McGuire (MVEC Education Nurse Coordinator)<\/span><\/span><\/p>\n<p><strong>Date:<\/strong> February 2024<\/p>\n<p>Materials in this section are updated as new information and vaccines become available. The Melbourne Vaccine Education Centre (MVEC) staff regularly reviews materials for accuracy.<\/p>\n<p>You should not consider the information on this site to be specific, professional medical advice for your personal health or for your family\u2019s personal health. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult a healthcare professional.<\/p>\n<\/div>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/div><script id=\"script-row-unique-0\" data-row=\"script-row-unique-0\" type=\"text\/javascript\" class=\"vc_controls\">UNCODE.initRow(document.getElementById(\"row-unique-0\"));<\/script><\/div><\/div><\/div>\n<\/div>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":"","_wp_rev_ctl_limit":""},"first_letter":[26],"class_list":["post-1079","references","type-references","status-publish","hentry","first_letter-r"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rabies - The Melbourne Vaccine Education Centre (MVEC)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mvec.mcri.edu.au\/zh\/\u53c2\u8003\/rabies\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rabies - 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