背景
Immunosuppressive therapies play an important role in the treatment of many medical conditions. Biologic disease-modifying anti-rheumatic drugs (bDMARDs) are a specific subset of immunosuppressive medications primarily used for the treatment of inflammatory rheumatic diseases. However, they are increasingly being used to treat many other conditions. Examples of bDMARDs include adalimumab, tocilizumab, etanercept, infliximab and rituximab.
If exposed to vaccine-preventable diseases, individuals with suppressed immune systems may have an increased risk of developing severe disease (and of hospitalisation, intensive care admission and death). However, some vaccines (live-attenuated vaccines) may be contraindicated in individuals with immunosuppression due to the potential risk of vaccine-related disease. Additionally, immune response秒 to vaccines may be suboptimal.
Immunosuppression use in pregnancy infant
Due to the broadened scope of use 的 bDMARDs, including during pregnancy, there is an increasing number of infants exposed to bDMARDs in utero. The effect that this has on an infant’s immune system is not well understood, but there is 这 potential 为了 significant implications regarding the safe use and effectiveness of routine and 额外的 vaccines in infants.
建议
Specific guidance on the immunisation of infants exposed to immunosuppressive therapy in utero or through breastmilk is outlined in the Australian Immunisation Handbook. Access the guidance 这里.
资源
作者： Angela Berkhout (Paediatric Infectious Diseases Physician & General Paediatrician, Children’s Health Queensland), Sophie Wen (Paediatric Infection Specialist, Children’s Health Queensland) , Michael Nissen (Infectious Diseases, Microbiology and Paediatric Consultant, Royal Brisbane and Women’s Hospital), Rachael McGuire (MVEC Education Nurse Coordinator) and Nigel Crawford (Director, SAEFVIC and MVEC, Murdoch Children’s Research Institute)
审核人： Angela Berkhout (Paediatric Infectious Diseases Physician & General Paediatrician, Children’s Health Queensland)
日期： June 2025
本章节内的材料将随着新信息和新疫苗的出现而进行更新。墨尔本疫苗教育中心（MVEC）职员定期审阅材料的准确性。
You should not consider the information on this site to be specific, professional medical advice for your personal health or for your family’s personal health. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult a healthcare professional.