Injection site reactions (ISRs) are a common localised side effect that can occur following the administration of any injected vaccine.

We have recently updated our injection site reaction reference page to provide more information on the diagnosis of ISRs, to detail factors associated with a higher incidence of ISRs and to clarify the proper treatment of ISRs.

ISRs resolve on their own without intervention. They can be managed at home with symptomatic relief. ISRs are not a sign of allergy or local infection. Therefore antihistamines, steroids or antibiotics are not required.