SMH: The flu shot: when is it safe to get it after having COVID?
With flu season underway in Australia and an increasing number of cases already confirmed, people are encouraged not to delay their yearly influenza vaccine, which is recommended for anyone 6 months of age and over.
The article features MVEC’s A/Prof Nigel Crawford, who addresses the key considerations such as ideal timing for the influenza vaccination, considerations for people with underlying medical conditions, advice for parents regarding children, and when to get the influenza vaccine post COVID-19 infection.
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SMH: The flu shot: when is it safe to get it after having COVID?
有关流感疫苗和 2022 年流感季节的更多信息，请参阅我们的以下资源：
Moderna: COVID-19 Vaccine Phase 2/3 Study in Children 6 Months to ≤ 6 Years successfully meets its primary endpoint
Moderna has announced interim data from the Phase 2/3 KidCOVE COVID-19 vaccine study ahead of its submission to global regulatory bodies.
Approximately 4,200 children aged 2 to <6 years and 2,500 children aged 6 months to <2 years were recruited across the U.S. and Canada with participants receiving 2 doses of 25 μg, 28 days apart (a lower dose compared with older age groups).
Moderna reports immunogenicity consistent with that seen in adults (18-25 years) receiving doses of 100mcg with a vaccine efficacy of 43.7% in those aged 6 months to <2 years and 37.5% in those aged 2 to <6 years. Omicron was the predominant COVID-19 strain circulating during this trial.
Adverse events following vaccination were reported as mild or moderate and more frequently associated with dose two. No deaths, myocarditis, pericarditis, or cases of multisystem inflammatory syndrome in children (MIS-C) were reported. Independent safety monitoring will continue for 12 months following the second dose.
To read the press release in full, please click on the link below:
COVID-19 Vaccine Phase 2/3 Study in Children 6 Months to ≤ 6 Years successfully meets its primary endpoint
ATAGI 关于冬季加强剂量 COVID-19 疫苗建议的声明
作为冬季准备工作的一部分，ATAGI 已为被确定为患严重 COVID-19 疾病风险最高的特定人群提供了额外的 COVID-19 疫苗冬季加强剂量的建议。 这些团体包括：
- ≥ 65 岁的个人
- 老年护理或残疾护理机构的居民
- ≥ 16 岁的个人 严重的免疫功能低下
- 50 岁以上的原住民和托雷斯海峡岛民。
根据 2022 年流感疫苗接种计划，将于 4 月开始推出冬季加强剂，两种疫苗可以在适当的情况下联合接种。 COVID-19 疫苗的冬季加强剂量可以从前一次加强剂量/确认的 SARS-CoV-2 感染（以较晚者为准）起 ≥ 4 个月开始接种。
mRNA 疫苗（Comirnaty（辉瑞）或 Spikevax（Moderna））仍然是用作加强剂量的推荐品牌，Vaxzevria（阿斯利康）可用于对 mRNA 疫苗有禁忌症的人。 Nuvaxovid (Novavax) 可用于认为没有其他疫苗品牌适合的情况。
ATAGI 表示，目前没有足够的证据支持为其他人提供额外助推器的建议。对于这些群体，通过 COVID-19 疫苗初级疗程和随后的 1 剂加强剂的保护继续提供良好的保护，避免因 COVID-19 疾病住院。随着更多证据的出现，未来可能会考虑进一步的建议。
要完整阅读建议，请点击以下链接。
ATAGI 关于冬季加强剂量 COVID-19 疫苗建议的声明
《纽约时报》：在非洲，多种枪击事件推动了不确定的新冠疫苗接种进程
尽管许多富裕国家在使用辉瑞和 Moderna 疫苗进行 COVID-19 加强疫苗接种方面进展顺利，但非洲国家仍然依赖许多研究人员认为会降低疫苗功效的产品和给药方案。
整个非洲大陆的新冠疫苗接种率平均约为 14%，专家透露，疫苗接种存在一些需要考虑的障碍，并警告第五波可能更致命的浪潮即将到来。
请点击以下链接阅读全文：
《纽约时报》：在非洲，多种枪击事件推动了不确定的新冠疫苗接种进程
CDC: Effectiveness of COVID-19 Pfizer-BioNTech BNT162b2 mRNA Vaccination in Preventing COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Nonimmunocompromised Children and Adolescents Aged 5–17 Years
A recent study conducted by the CDC and the VISION Network examined 39,217 emergency department (ED), urgent care (UC) encounters and 1,699 hospitalisations among persons aged 5 to 17 years with COVID-19–like illness during April 9, 2021–January 29, 2022. The study employed a case-control test-negative design to estimate the VE of two doses of the Pfizer-BioNTech vaccine in preventing COVID-19 associated hospitalisations in this cohort.
Click on the link below to access the study findings:
CDC: Effectiveness of 2-Dose BNT162b2 (Pfizer BioNTech) mRNA Vaccine in Preventing SARS-CoV-2 Infection Among Children Aged 5–11 Years and Adolescents Aged 12–15 Years — PROTECT Cohort
The CDC has released the findings of a recent PROTECT study, assessing the efficacy of two doses of Pfizer-BioNTech vaccine in preventing infection from the Omicron variant amongst children 5 to 11 and adolescents 12 to 15 years of age. The study included clinical data from a cohort of 1,364 participants gathered from July 2021 to February 2022.
The report provides evidence that two doses of the Pfizer-BioNTech vaccine is effective in preventing both asymptomatic and symptomatic SARS-CoV-2 infection in this cohort.
Click on the link below to read the full report:
New resource: NCIRS Decision aid (5–15 years): Should I get the COVID-19 vaccine for my child?
NCIRS have designed a new decision aid resource to help families make an informed decision about whether COVID-19 vaccination is right for their children.
The tool provides evidence-based information about the disease and the vaccine and takes the user through five simple steps to help weigh up the risks and benefits of vaccination.
To access the decision guide, please click on the link below.
New resource: NCIRS Decision aid (5–15 years): Should I get the COVID-19 vaccine for my child?
COVID-19 疫苗的临床建议 - 更新的加强建议
澳大利亚免疫技术咨询小组 (ATAGI) 提供了关于使用加强剂量的 COVID-19 疫苗的最新建议：
- 建议 18 岁及以上的个人接受单次加强剂量的任一 mRNA 疫苗（辉瑞公司 或者 现代), 初级疫苗接种完成后 3 个月。
- 建议 16-17 岁的个人在完成主要课程后 3 个月接受单剂 Comirnaty（辉瑞）作为他们的助推器。其他 COVID-19 疫苗品牌未注册用作该年龄段的加强剂量。
- 同时 Nuvaxovid (Novavax) 未在 TGA 注册用作加强剂量，ATAGI 建议在存在 mRNA 疫苗禁忌症的情况下，可将其用作 18 岁或以上个人的加强剂。支持使用 Nuvaxovid 作为加强剂量的安全性和有效性数据有限，但没有理论上的担忧。
- Vaxzevria（阿斯利康） 不再推荐用作加强剂量。已经接受 Vaxzevria（阿斯利康）作为加强剂的个人不需要重复服用替代品牌的加强剂。
有关 ATAGI 关于使用加强剂量的 COVID-19 疫苗的建议的更多信息，请参阅以下链接：
ATAGI 关于使用加强剂量的 COVID-19 疫苗的建议
ATAGI recommendations on the use of Spikevax (Moderna) COVID-19 vaccine in children aged 6 to 11 years
Following the TGA’s provisional approval, ATAGI has put forth a guideline that recommends the use of Moderna’s COVID-19 vaccine (Spikevax) in children aged 6 to 11 years.
Clinical data supports that Spikevax produces a strong immune response and reduces the likelihood of children in this cohort developing COVID-19.
This statement addresses the recommendations, considerations and rationale for the use of Moderna’s COVID-19 vaccine in children aged 6 to 11.
To read the full statement, follow the link below.
The Conversation: The Moderna vaccine is now available for 6 to 11 year olds. Here’s what parents need to know
The Moderna COVID-19 vaccine is now approved for use in children aged 6 to 11 years. With just under half of Australian primary-school-age children having received their first COVID vaccine dose, the approval of Moderna’s COVID vaccine provides parents with an additional opportunity to protect their children against severe disease.
Following the KidCOVE clinical trial, this article explores the ongoing safety and efficacy as well as the considerations and administrative recommendations for the use of Moderna’s COVID-19 vaccine in the 6 to 11 years cohort.
To read the full article, follow the link below.