NEJM: Evaluating and Deploying Covid-19 Vaccines — The Importance of Transparency, Scientific Integrity, and Public Trust
The following article published in the New England Journal of Medicine, discusses the importance of adhering to well-established and transparent regulatory processes when it comes to approving a COVID-19 vaccine. Reassuring the public with robust scientific evaluation from independent bodies, without interference from governments for the purposes of political advantage, is essential to promote public confidence and ensure the success of vaccination programs.
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新冠疫苗之路第 14 集：布鲁斯·杰林博士
在第 14 集中，我们的主持人 Nigel Crawford 副教授与 Bruce Gellin 博士进行了对话。布鲁斯是华盛顿萨宾疫苗研究所全球免疫部门的主席。萨宾疫苗研究所的使命是让疫苗更容易获得、促进创新并在全球范围内扩大免疫接种范围。 Bruce 于 2017 年担任这一职务，在此之前，他担任美国卫生与公众服务部国家疫苗计划办公室副助理部长，并担任世界卫生组织的技术和政策顾问，重点关注流感疫苗和全球疫苗接种问题。疫苗犹豫问题。布鲁斯还曾在疾病控制和预防中心 (CDC) 工作，为全球疫苗和免疫联盟提供咨询，并且是美国疫苗和免疫接种方面的主要发言人之一。他和奈杰尔在疫苗信心的背景下讨论了以下内容：
- 牛津阿斯利康试验最近停止，以及现有系统如何完全发挥作用
- “刀具事件”及其对疫苗安全性的持续影响，特别是从生产角度来看
- 确保免疫提供者了解疫苗开发过程非常重要，就好像他们不了解并且持怀疑态度一样，这会对疫苗的吸收产生巨大影响
- 公开披露在疫苗开发途径中的重要性
- 萨宾疫苗研究所如何应对疫苗犹豫的挑战
- 萨宾针对医护人员的“Boost”计划
- 疫苗使用后如何进行监测，也称为 IV 期监测
链接：
- 萨宾疫苗研究所
- 对话：停止牛津疫苗试验并不意味着它不安全——这表明他们正在遵循正确的程序
- 保罗·奥菲特的《刀具事件》
- 萨宾疫苗研究所：免疫倡导者
- 萨宾疫苗研究所：Boost
- 《柳叶刀》：绘制疫苗信心的全球趋势并调查疫苗接种的障碍：一项大规模回顾性时间模型研究
- 《柳叶刀》：是时候认真对待疫苗信心了
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喇叭 - 苹果 - Spotify 音乐
COVID19 Road to a vaccine episode 13: Professor Kim Mulholland
In episode 13, our host, Associate Professor Nigel Crawford, speaks to Professor Kim Mulholland. Kim is a paediatrician and Professor of Child Health from the Murdoch Children’s Research Institute, the University of Melbourne department of Paediatrics and the London School of Hygiene and Tropical Medicine. With post-graduate training in immunology, respiratory medicine and tropical medicine, his vast experience includes developing a program of research covering all aspects of childhood pneumonia which helped guide WHO policies. He has been involved in the oversight of many vaccine trials and has served on steering committees or DSMBs for a range of vaccines including pneumococcal, dengue, RSV and COVID-19. He and Nigel discuss:
- global issues brought about by the SARS-CoV-2 pandemic and some of the surprising ways the virus has spread globally
- what we can learn from seroprevalence in countries such as India
- vaccine nationalism and the push for global solidarity
- the role of Australia in the pacific region in regards to vaccine preparedness
- global, equitable access to COVID-19 vaccines
链接：
- Developing a Low-Cost and Accessible COVID-19 Vaccine for Global Health
- WHO Chief Urges Nations to Join in Preventing ‘Vaccine Nationalism’
- Africa declared free of wild polio
- The Meningitis Vaccine Project: A groundbreaking partnership
- GAVI vaccine alliance
Listen here:
喇叭 - 苹果 - Spotify 音乐
Halting the Oxford vaccine trial doesn't mean it's not safe- it shows they're following the right process
Due to a single event of an unexplained illness, the AstraZeneca Oxford group have announced a voluntary pause on all vaccinations across all sites of their COVID-19 vaccine candidate clinical trial. This pause will allow an independent committee to review the safety data and investigate the incident.
The following article, published in The Conversation, outlines how this halt doesn't necessarily indicate that the vaccine is not safe, but reflects the robust processes for clinical trials. It is important to recognise that whilst these clinical trials are moving at pandemic speed, safety is not being compromised.
COVID19疫苗之路第12集：Heidi Larson教授
在本期《新冠疫苗之路》中，我们的主持人 Nigel Crawford 副教授与 Heidi Larson 教授进行了对话。海蒂是一位人类学家、疫苗信心项目主任、伦敦卫生与热带医学学院人类学教授。疫苗信心项目是世卫组织解决疫苗犹豫问题的卓越中心。海蒂是联合国儿童基金会全球免疫沟通的前任负责人，担任全球疫苗和免疫联盟倡导工作组的主席，并在世卫组织疫苗犹豫问题 SAGE 工作组中任职。在这一集中，他们讨论了：
- 海蒂如何以及为何创立疫苗信心项目
- 为什么在尚未有疫苗完成临床试验所有阶段的情况下，疫苗信心对于 SARS-CoV-2 疫苗来说已被证明如此重要
- 不同国家应对 SARS-CoV-2 大流行的方式是否会影响疫苗信心
- 医护人员对疫苗接种情况进行建模以提高疫苗信心的重要性
- 我们可以利用社交媒体促进疫苗准备的积极方式
- 对强制疫苗接种的抵制以及社区免疫与群体免疫的重要性
链接：
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喇叭 - 苹果 - Spotify 音乐
New immunisation reference page: Melbourne immunisation drive-through clinics
Staying up to date with scheduled and additional vaccinations, remains essential during the COVID-19 pandemic. Concerning results from the Royal Children’s Hospital (RCH) National Child Health Poll, indicate the impact that the pandemic has had on immunisation, with data showing 1 in 5 children have had those vaccinations delayed since the beginning of the pandemic.
Families are reminded that it is safe and recommended to attend local immunisation providers (GP or local council) for vaccinations, however drive-through clinics are also available at Monash Health in Clayton and the RCH in Parkville.
For more information please refer to the following:
MVEC: Melbourne immunisation drive-through clinics
COVID19疫苗之路第11集：Margie Danchin副教授和Julie Leask教授
在我们的新冠疫苗之路系列的第 11 集中，我们的主持人 Nigel Crawford 与疫苗信心专家 Margie Danchin 副教授和 Julie Leask 教授进行了交谈。玛吉是皇家儿童医院的儿科医生顾问、墨尔本大学儿科和默多克儿童研究所的副教授，她是默多克儿童研究所疫苗摄取小组的负责人。 Julie 是悉尼大学医学与健康学院苏珊瓦基尔护理与助产学院的社会科学家和教授，也是 NCIRS（国家免疫研究与监测中心）的客座教授研究员。在这一集中，他们讨论了：
- 从澳大利亚的角度应对疫苗犹豫并增强疫苗信心
- 在疫苗信心、犹豫和接受方面，语言和定义的重要性
- (5) 让公众为 SARS-CoV-2 疫苗做好准备的重要方法
- 社交媒体平台在传达这些信息方面的作用
- 衡量社区对疫苗信心的重要性
- 围绕不良事件进行良好沟通以赢得社区信任和维持疫苗计划的方法，包括利用专业免疫诊所 (SIC) 的专业知识
链接：
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喇叭 - 苹果 - Spotify 音乐
The use of foetal tissue in vaccine development
There has been attention in the media recently regarding the use of foetal cell lines by the Oxford Vaccine Group to develop their COVID-19 vaccine candidate. Cell lines are currently used to manufacture many vaccines including varicella, hepatitis A, rabies and MMR vaccines.
The below information from the Children's Hospital of Philadelphia (CHoP) discusses the background behind using these cell lines in vaccine development as well as any potential ethical or religious concerns surrounding this.
Vaccine ingredients- Fetal tissues
The RCH Immunisation Service: Drive-through clinic is now open
To support families in continuing to receive scheduled vaccinations during the COVID-19 pandemic, the RCH Immunisation Service has just opened its own immunisation drive-through clinic. Additional precautions have been implemented to ensure the safety of all patients, families and staff. Access to medical care remains an essential service during this time and staying up to date with scheduled immunisations is encouraged.
The drive-through clinic will operate on Tuesdays and Wednesdays from 9am - 1pm until September 15.
Bookings for the drive-through clinic are mandatory and can be made by contacting the immunisation team via this link.
COVID19疫苗之路第10集：Paul Young教授和Trent Munro教授
在我们的 COVID19 疫苗之路系列的第 10 集中，我们的主持人 Nigel Crawford 与 Paul Young 教授和 Trent Munro 教授讨论了昆士兰大学 (UQ) 的 COVID-19 候选疫苗。昆士兰大学和 CEPI（流行病防范与创新联盟）与 CSL (Seqirus) 合作，推进其新型分子钳技术，以开发针对 COVID-19 的疫苗。该疫苗最近已进入一期临床试验。在这一集中，他们讨论了：
- 昆士兰大学新冠肺炎疫苗研发流程
- CEPI 参与他们的试验
- 使用分子钳平台开发蛋白质 SARS-CoV-2 疫苗
- 他们的临床前试验结果
- 他们与 CSL/Seqirus 的合作以及 MF59 佐剂的使用
- 他们的临床试验的时间表和接下来的步骤
链接：
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喇叭 - 苹果 - Spotify 音乐